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Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity.
Bianco A, Reghellin V, Donnici L, Fenu S, Alvarez R, Baruffa C, Peri F, Pagani M, Abrignani S, Neddermann P, De Francesco R. Bianco A, et al. Among authors: reghellin v. PLoS Pathog. 2012;8(3):e1002576. doi: 10.1371/journal.ppat.1002576. Epub 2012 Mar 8. PLoS Pathog. 2012. PMID: 22412376 Free PMC article.
NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase IIIα complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes.
Reghellin V, Donnici L, Fenu S, Berno V, Calabrese V, Pagani M, Abrignani S, Peri F, De Francesco R, Neddermann P. Reghellin V, et al. Antimicrob Agents Chemother. 2014 Dec;58(12):7128-40. doi: 10.1128/AAC.03293-14. Epub 2014 Sep 15. Antimicrob Agents Chemother. 2014. PMID: 25224012 Free PMC article.
CK2 activity is modulated by growth rate in Saccharomyces cerevisiae.
Tripodi F, Cirulli C, Reghellin V, Marin O, Brambilla L, Schiappelli MP, Porro D, Vanoni M, Alberghina L, Coccetti P. Tripodi F, et al. Among authors: reghellin v. Biochem Biophys Res Commun. 2010 Jul 16;398(1):44-50. doi: 10.1016/j.bbrc.2010.06.028. Epub 2010 Jun 17. Biochem Biophys Res Commun. 2010. PMID: 20599749
Enhanced amino acid utilization sustains growth of cells lacking Snf1/AMPK.
Nicastro R, Tripodi F, Guzzi C, Reghellin V, Khoomrung S, Capusoni C, Compagno C, Airoldi C, Nielsen J, Alberghina L, Coccetti P. Nicastro R, et al. Among authors: reghellin v. Biochim Biophys Acta. 2015 Jul;1853(7):1615-25. doi: 10.1016/j.bbamcr.2015.03.014. Epub 2015 Apr 2. Biochim Biophys Acta. 2015. PMID: 25841981 Free article.
Methionine supplementation stimulates mitochondrial respiration.
Tripodi F, Castoldi A, Nicastro R, Reghellin V, Lombardi L, Airoldi C, Falletta E, Maffioli E, Scarcia P, Palmieri L, Alberghina L, Agrimi G, Tedeschi G, Coccetti P. Tripodi F, et al. Among authors: reghellin v. Biochim Biophys Acta Mol Cell Res. 2018 Dec;1865(12):1901-1913. doi: 10.1016/j.bbamcr.2018.09.007. Epub 2018 Oct 2. Biochim Biophys Acta Mol Cell Res. 2018. PMID: 30290237 Free article.