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Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.
Ashrafian H, Czibik G, Bellahcene M, Aksentijević D, Smith AC, Mitchell SJ, Dodd MS, Kirwan J, Byrne JJ, Ludwig C, Isackson H, Yavari A, Støttrup NB, Contractor H, Cahill TJ, Sahgal N, Ball DR, Birkler RI, Hargreaves I, Tennant DA, Land J, Lygate CA, Johannsen M, Kharbanda RK, Neubauer S, Redwood C, de Cabo R, Ahmet I, Talan M, Günther UL, Robinson AJ, Viant MR, Pollard PJ, Tyler DJ, Watkins H. Ashrafian H, et al. Among authors: tennant da. Cell Metab. 2012 Mar 7;15(3):361-71. doi: 10.1016/j.cmet.2012.01.017. Cell Metab. 2012. PMID: 22405071 Free PMC article.
A role for cytosolic fumarate hydratase in urea cycle metabolism and renal neoplasia.
Adam J, Yang M, Bauerschmidt C, Kitagawa M, O'Flaherty L, Maheswaran P, Özkan G, Sahgal N, Baban D, Kato K, Saito K, Iino K, Igarashi K, Stratford M, Pugh C, Tennant DA, Ludwig C, Davies B, Ratcliffe PJ, El-Bahrawy M, Ashrafian H, Soga T, Pollard PJ. Adam J, et al. Among authors: tennant da. Cell Rep. 2013 May 30;3(5):1440-8. doi: 10.1016/j.celrep.2013.04.006. Epub 2013 May 2. Cell Rep. 2013. PMID: 23643539 Free PMC article.
Probing Cancer Cell Metabolism Using NMR Spectroscopy.
Hollinshead KE, Williams DS, Tennant DA, Ludwig C. Hollinshead KE, et al. Among authors: tennant da. Adv Exp Med Biol. 2016;899:89-111. doi: 10.1007/978-3-319-26666-4_6. Adv Exp Med Biol. 2016. PMID: 27325263 Review.
Metabolic plasticity in CLL: adaptation to the hypoxic niche.
Koczula KM, Ludwig C, Hayden R, Cronin L, Pratt G, Parry H, Tennant D, Drayson M, Bunce CM, Khanim FL, Günther UL. Koczula KM, et al. Leukemia. 2016 Jan;30(1):65-73. doi: 10.1038/leu.2015.187. Epub 2015 Jul 23. Leukemia. 2016. PMID: 26202928 Free PMC article.
Combined Analysis of NMR and MS Spectra (CANMS).
Chong M, Jayaraman A, Marin S, Selivanov V, de Atauri Carulla PR, Tennant DA, Cascante M, Günther UL, Ludwig C. Chong M, et al. Among authors: tennant da. Angew Chem Int Ed Engl. 2017 Apr 3;56(15):4140-4144. doi: 10.1002/anie.201611634. Epub 2017 Mar 8. Angew Chem Int Ed Engl. 2017. PMID: 28272839
Intracellular sodium elevation reprograms cardiac metabolism.
Aksentijević D, Karlstaedt A, Basalay MV, O'Brien BA, Sanchez-Tatay D, Eminaga S, Thakker A, Tennant DA, Fuller W, Eykyn TR, Taegtmeyer H, Shattock MJ. Aksentijević D, et al. Among authors: tennant da. Nat Commun. 2020 Aug 28;11(1):4337. doi: 10.1038/s41467-020-18160-x. Nat Commun. 2020. PMID: 32859897 Free PMC article.
110 results