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Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.
Ashrafian H, Czibik G, Bellahcene M, Aksentijević D, Smith AC, Mitchell SJ, Dodd MS, Kirwan J, Byrne JJ, Ludwig C, Isackson H, Yavari A, Støttrup NB, Contractor H, Cahill TJ, Sahgal N, Ball DR, Birkler RI, Hargreaves I, Tennant DA, Land J, Lygate CA, Johannsen M, Kharbanda RK, Neubauer S, Redwood C, de Cabo R, Ahmet I, Talan M, Günther UL, Robinson AJ, Viant MR, Pollard PJ, Tyler DJ, Watkins H. Ashrafian H, et al. Among authors: contractor h. Cell Metab. 2012 Mar 7;15(3):361-71. doi: 10.1016/j.cmet.2012.01.017. Cell Metab. 2012. PMID: 22405071 Free PMC article.
Remote ischemic preconditioning with--but not without--metabolic support protects the neonatal porcine heart against ischemia-reperfusion injury.
Schmidt MR, Støttrup NB, Contractor H, Hyldebrandt JA, Johannsen M, Pedersen CM, Birkler R, Ashrafian H, Sørensen KE, Kharbanda RK, Redington AN, Bøtker HE. Schmidt MR, et al. Among authors: contractor h. Int J Cardiol. 2014 Jan 1;170(3):388-93. doi: 10.1016/j.ijcard.2013.11.020. Epub 2013 Nov 12. Int J Cardiol. 2014. PMID: 24280512
Remote ischemic preconditioning impairs ventricular function and increases infarct size after prolonged ischemia in the isolated neonatal rabbit heart.
Schmidt MR, Støttrup NB, Michelsen MM, Contractor H, Sørensen KE, Kharbanda RK, Redington AN, Bøtker HE. Schmidt MR, et al. Among authors: contractor h. J Thorac Cardiovasc Surg. 2014 Mar;147(3):1049-55. doi: 10.1016/j.jtcvs.2013.05.022. Epub 2013 Jul 18. J Thorac Cardiovasc Surg. 2014. PMID: 23871143 Free article.
Adenosine Receptor Activation in the "Trigger" Limb of Remote Pre-Conditioning Mediates Human Endothelial Conditioning and Release of Circulating Cardioprotective Factor(s).
Contractor H, Lie RH, Cunnington C, Li J, Støttrup NB, Manlhiot C, Bøtker HE, Schmidt MR, Forfar JC, Ashrafian H, Redington A, Kharbanda RK. Contractor H, et al. JACC Basic Transl Sci. 2016 Sep 28;1(6):461-471. doi: 10.1016/j.jacbts.2016.06.002. eCollection 2016 Oct. JACC Basic Transl Sci. 2016. PMID: 30167533 Free PMC article.
Elevated blood pressure in offspring born premature to hypertensive pregnancy: is endothelial dysfunction the underlying vascular mechanism?
Lazdam M, de la Horra A, Pitcher A, Mannie Z, Diesch J, Trevitt C, Kylintireas I, Contractor H, Singhal A, Lucas A, Neubauer S, Kharbanda R, Alp N, Kelly B, Leeson P. Lazdam M, et al. Among authors: contractor h. Hypertension. 2010 Jul;56(1):159-65. doi: 10.1161/HYPERTENSIONAHA.110.150235. Epub 2010 May 17. Hypertension. 2010. PMID: 20479334
Rotigaptide protects the myocardium and arterial vasculature from ischaemia reperfusion injury.
Pedersen CM, Venkatasubramanian S, Vase H, Hyldebrandt JA, Contractor H, Schmidt MR, Bøtker HE, Cruden NL, Newby DE, Kharbanda RK, Lang NN. Pedersen CM, et al. Among authors: contractor h. Br J Clin Pharmacol. 2016 Jun;81(6):1037-45. doi: 10.1111/bcp.12882. Epub 2016 Mar 10. Br J Clin Pharmacol. 2016. PMID: 26750458 Free PMC article. Clinical Trial.
Human Second Window Pre-Conditioning and Post-Conditioning by Nitrite Is Influenced by a Common Polymorphism in Mitochondrial Aldehyde Dehydrogenase.
Ormerod JO, Evans JD, Contractor H, Beretta M, Arif S, Fernandez BO, Feelisch M, Mayer B, Kharbanda RK, Frenneaux MP, Ashrafian H. Ormerod JO, et al. Among authors: contractor h. JACC Basic Transl Sci. 2017 Feb 15;2(1):13-21. doi: 10.1016/j.jacbts.2016.11.006. eCollection 2017 Feb. JACC Basic Transl Sci. 2017. PMID: 28280793 Free PMC article.
Influence of long-term treatment with glyceryl trinitrate on remote ischemic conditioning.
Hauerslev M, Mørk SR, Pryds K, Contractor H, Hansen J, Jespersen NR, Johnsen J, Heusch G, Kleinbongard P, Kharbanda R, Bøtker HE, Schmidt MR. Hauerslev M, et al. Among authors: contractor h. Am J Physiol Heart Circ Physiol. 2018 Jul 1;315(1):H150-H158. doi: 10.1152/ajpheart.00114.2018. Epub 2018 Mar 23. Am J Physiol Heart Circ Physiol. 2018. PMID: 29569958 Free article.
66 results