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An epigenetic blockade of cognitive functions in the neurodegenerating brain.
Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I, Tsai LH. Gräff J, et al. Among authors: haggarty sj. Nature. 2012 Feb 29;483(7388):222-6. doi: 10.1038/nature10849. Nature. 2012. PMID: 22388814 Free PMC article.
A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy.
Eteläinen TS, Silva MC, Uhari-Väänänen JK, De Lorenzo F, Jäntti MH, Cui H, Chavero-Pieres M, Kilpeläinen T, Mechtler C, Svarcbahs R, Seppälä E, Savinainen JR, Puris E, Fricker G, Gynther M, Julku UH, Huttunen HJ, Haggarty SJ, Myöhänen TT. Eteläinen TS, et al. Among authors: haggarty sj. Sci Transl Med. 2023 Apr 12;15(691):eabq2915. doi: 10.1126/scitranslmed.abq2915. Epub 2023 Apr 12. Sci Transl Med. 2023. PMID: 37043557
Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity.
Kim D, Frank CL, Dobbin MM, Tsunemoto RK, Tu W, Peng PL, Guan JS, Lee BH, Moy LY, Giusti P, Broodie N, Mazitschek R, Delalle I, Haggarty SJ, Neve RL, Lu Y, Tsai LH. Kim D, et al. Among authors: haggarty sj. Neuron. 2008 Dec 10;60(5):803-17. doi: 10.1016/j.neuron.2008.10.015. Neuron. 2008. PMID: 19081376 Free PMC article.
HDAC2 negatively regulates memory formation and synaptic plasticity.
Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, Tsai LH. Guan JS, et al. Among authors: haggarty sj. Nature. 2009 May 7;459(7243):55-60. doi: 10.1038/nature07925. Nature. 2009. PMID: 19424149 Free PMC article.
An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.
Marcaurelle LA, Comer E, Dandapani S, Duvall JR, Gerard B, Kesavan S, Lee MD 4th, Liu H, Lowe JT, Marie JC, Mulrooney CA, Pandya BA, Rowley A, Ryba TD, Suh BC, Wei J, Young DW, Akella LB, Ross NT, Zhang YL, Fass DM, Reis SA, Zhao WN, Haggarty SJ, Palmer M, Foley MA. Marcaurelle LA, et al. Among authors: haggarty sj. J Am Chem Soc. 2010 Dec 1;132(47):16962-76. doi: 10.1021/ja105119r. Epub 2010 Nov 10. J Am Chem Soc. 2010. PMID: 21067169 Free PMC article.
170 results