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The single-stranded DNA-binding factor SUB1/PC4 alleviates replication stress at telomeres and is a vulnerability of ALT cancer cells.
Dubois JC, Bonnell E, Filion A, Frion J, Zimmer S, Riaz Khan M, Teplitz GM, Casimir L, Méthot É, Marois I, Idrissou M, Jacques PÉ, Wellinger RJ, Maréchal A. Dubois JC, et al. Among authors: marechal a. Proc Natl Acad Sci U S A. 2025 Jan 14;122(2):e2419712122. doi: 10.1073/pnas.2419712122. Epub 2025 Jan 7. Proc Natl Acad Sci U S A. 2025. PMID: 39772744
Heterozygous RPA2 variant as a novel genetic cause of telomere biology disorders.
Kochman R, Ba I, Yates M, Pirabakaran V, Gourmelon F, Churikov D, Laffaille M, Kermasson L, Hamelin C, Marois I, Jourquin F, Braud L, Bechara M, Lainey E, Nunes H, Breton P, Penhouet M, David P, Géli V, Lachaud C, Maréchal A, Revy P, Kannengiesser C, Saintomé C, Coulon S. Kochman R, et al. Among authors: marechal a. Genes Dev. 2024 Sep 19;38(15-16):755-771. doi: 10.1101/gad.352032.124. Genes Dev. 2024. PMID: 39231615 Free PMC article.
Non-viral DNA delivery and TALEN editing correct the sickle cell mutation in hematopoietic stem cells.
Moiani A, Letort G, Lizot S, Chalumeau A, Foray C, Felix T, Le Clerre D, Temburni-Blake S, Hong P, Leduc S, Pinard N, Marechal A, Seclen E, Boyne A, Mayer L, Hong R, Pulicani S, Galetto R, Gouble A, Cavazzana M, Juillerat A, Miccio A, Duclert A, Duchateau P, Valton J. Moiani A, et al. Among authors: marechal a. Nat Commun. 2024 Jun 11;15(1):4965. doi: 10.1038/s41467-024-49353-3. Nat Commun. 2024. PMID: 38862518 Free PMC article.
SMARCAL1 ubiquitylation controls its association with RPA-coated ssDNA and promotes replication fork stability.
Yates M, Marois I, St-Hilaire E, Ronato DA, Djerir B, Brochu C, Morin T, Hammond-Martel I, Gezzar-Dandashi S, Casimir L, Drobetsky E, Cappadocia L, Masson JY, Wurtele H, Maréchal A. Yates M, et al. Among authors: marechal a. PLoS Biol. 2024 Mar 19;22(3):e3002552. doi: 10.1371/journal.pbio.3002552. eCollection 2024 Mar. PLoS Biol. 2024. PMID: 38502677 Free PMC article.
122 results