Zhang Y - Search Results

1

Design and synthesis of cannabinoid receptor 1 antagonists for peripheral selectivity.

Fulp A, Bortoff K, Seltzman H, Zhang Y, Mathews J, Snyder R, Fennell T, Maitra R. Fulp A, et al. Among authors: zhang y. J Med Chem. 2012 Mar 22;55(6):2820-34. doi: 10.1021/jm201731z. Epub 2012 Mar 9. J Med Chem. 2012. PMID: 22372835 Free PMC article.

2

Conformationally constrained analogues of N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4- dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716): design, synthesis, computational analysis, and biological evaluations.

Zhang Y, Burgess JP, Brackeen M, Gilliam A, Mascarella SW, Page K, Seltzman HH, Thomas BF. Zhang Y, et al. J Med Chem. 2008 Jun 26;51(12):3526-39. doi: 10.1021/jm8000778. J Med Chem. 2008. PMID: 18512901

3

Synthesis and biological evaluation of bivalent ligands for the cannabinoid 1 receptor.

Zhang Y, Gilliam A, Maitra R, Damaj MI, Tajuba JM, Seltzman HH, Thomas BF. Zhang Y, et al. J Med Chem. 2010 Oct 14;53(19):7048-60. doi: 10.1021/jm1006676. J Med Chem. 2010. PMID: 20845959 Free PMC article.

4

Towards rational design of cannabinoid receptor 1 (CB1) antagonists for peripheral selectivity.

Fulp A, Bortoff K, Zhang Y, Seltzman H, Snyder R, Maitra R. Fulp A, et al. Among authors: zhang y. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5711-4. doi: 10.1016/j.bmcl.2011.08.032. Epub 2011 Aug 11. Bioorg Med Chem Lett. 2011. PMID: 21875798 Free PMC article.

5

Diphenyl purine derivatives as peripherally selective cannabinoid receptor 1 antagonists.

Fulp A, Bortoff K, Zhang Y, Seltzman H, Mathews J, Snyder R, Fennell T, Maitra R. Fulp A, et al. Among authors: zhang y. J Med Chem. 2012 Nov 26;55(22):10022-32. doi: 10.1021/jm301181r. Epub 2012 Nov 9. J Med Chem. 2012. PMID: 23098108 Free PMC article.

6

Peripherally selective diphenyl purine antagonist of the CB1 receptor.

Fulp A, Bortoff K, Zhang Y, Snyder R, Fennell T, Marusich JA, Wiley JL, Seltzman H, Maitra R. Fulp A, et al. Among authors: zhang y. J Med Chem. 2013 Oct 24;56(20):8066-72. doi: 10.1021/jm401129n. Epub 2013 Sep 27. J Med Chem. 2013. PMID: 24041123 Free PMC article.

7

Pyrazole antagonists of the CB1 receptor with reduced brain penetration.

Fulp A, Zhang Y, Bortoff K, Seltzman H, Snyder R, Wiethe R, Amato G, Maitra R. Fulp A, et al. Among authors: zhang y. Bioorg Med Chem. 2016 Mar 1;24(5):1063-70. doi: 10.1016/j.bmc.2016.01.033. Epub 2016 Jan 18. Bioorg Med Chem. 2016. PMID: 26827137 Free PMC article.

8

Blocking Alcoholic Steatosis in Mice with a Peripherally Restricted Purine Antagonist of the Type 1 Cannabinoid Receptor.

Amato GS, Manke A, Harris DL, Wiethe RW, Vasukuttan V, Snyder RW, Lefever TW, Cortes R, Zhang Y, Wang S, Runyon SP, Maitra R. Amato GS, et al. Among authors: zhang y. J Med Chem. 2018 May 24;61(10):4370-4385. doi: 10.1021/acs.jmedchem.7b01820. Epub 2018 May 10. J Med Chem. 2018. PMID: 29688015 Free PMC article.

9

Conformational characteristics of the interaction of SR141716A with the CB1 cannabinoid receptor as determined through the use of conformationally constrained analogs.

Thomas BF, Zhang Y, Brackeen M, Page KM, Mascarella SW, Seltzman HH. Thomas BF, et al. Among authors: zhang y. AAPS J. 2006 Oct 27;8(4):E665-71. doi: 10.1208/aapsj080476. AAPS J. 2006. PMID: 17233530 Free PMC article.

10

Structural analogs of pyrazole and sulfonamide cannabinoids: effects on acute food intake in mice.

Wiley JL, Marusich JA, Zhang Y, Fulp A, Maitra R, Thomas BF, Mahadevan A. Wiley JL, et al. Among authors: zhang y. Eur J Pharmacol. 2012 Nov 15;695(1-3):62-70. doi: 10.1016/j.ejphar.2012.08.019. Epub 2012 Sep 6. Eur J Pharmacol. 2012. PMID: 22975289 Free PMC article.

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