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A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection.
Okumura CY, Hollands A, Tran DN, Olson J, Dahesh S, von Köckritz-Blickwede M, Thienphrapa W, Corle C, Jeung SN, Kotsakis A, Shalwitz RA, Johnson RS, Nizet V. Okumura CY, et al. Among authors: nizet v. J Mol Med (Berl). 2012 Sep;90(9):1079-89. doi: 10.1007/s00109-012-0882-3. Epub 2012 Feb 28. J Mol Med (Berl). 2012. PMID: 22371073 Free PMC article.
HIF-1alpha is essential for myeloid cell-mediated inflammation.
Cramer T, Yamanishi Y, Clausen BE, Förster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber HP, Ferrara N, Johnson RS. Cramer T, et al. Among authors: nizet v. Cell. 2003 Mar 7;112(5):645-57. doi: 10.1016/s0092-8674(03)00154-5. Cell. 2003. PMID: 12628185 Free PMC article.
Antimicrobial peptides and the skin.
Bardan A, Nizet V, Gallo RL. Bardan A, et al. Among authors: nizet v. Expert Opin Biol Ther. 2004 Apr;4(4):543-9. doi: 10.1517/14712598.4.4.543. Expert Opin Biol Ther. 2004. PMID: 15102603 Review.
HIF-1alpha expression regulates the bactericidal capacity of phagocytes.
Peyssonnaux C, Datta V, Cramer T, Doedens A, Theodorakis EA, Gallo RL, Hurtado-Ziola N, Nizet V, Johnson RS. Peyssonnaux C, et al. Among authors: nizet v. J Clin Invest. 2005 Jul;115(7):1806-15. doi: 10.1172/JCI23865. J Clin Invest. 2005. PMID: 16007254 Free PMC article.
567 results