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A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection.
Okumura CY, Hollands A, Tran DN, Olson J, Dahesh S, von Köckritz-Blickwede M, Thienphrapa W, Corle C, Jeung SN, Kotsakis A, Shalwitz RA, Johnson RS, Nizet V. Okumura CY, et al. Among authors: johnson rs. J Mol Med (Berl). 2012 Sep;90(9):1079-89. doi: 10.1007/s00109-012-0882-3. Epub 2012 Feb 28. J Mol Med (Berl). 2012. PMID: 22371073 Free PMC article.
Interdependence of hypoxic and innate immune responses.
Nizet V, Johnson RS. Nizet V, et al. Among authors: johnson rs. Nat Rev Immunol. 2009 Sep;9(9):609-17. doi: 10.1038/nri2607. Nat Rev Immunol. 2009. PMID: 19704417 Free PMC article. Review.
Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function.
Crotty Alexander LE, Akong-Moore K, Feldstein S, Johansson P, Nguyen A, McEachern EK, Nicatia S, Cowburn AS, Olson J, Cho JY, Isaacs H Jr, Johnson RS, Broide DH, Nizet V. Crotty Alexander LE, et al. Among authors: johnson rs. J Mol Med (Berl). 2013 May;91(5):637-44. doi: 10.1007/s00109-012-0986-9. Epub 2012 Dec 19. J Mol Med (Berl). 2013. PMID: 23250618 Free PMC article.
HIF transcription factors, inflammation, and immunity.
Palazon A, Goldrath AW, Nizet V, Johnson RS. Palazon A, et al. Among authors: johnson rs. Immunity. 2014 Oct 16;41(4):518-28. doi: 10.1016/j.immuni.2014.09.008. Immunity. 2014. PMID: 25367569 Free PMC article. Review.
445 results