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A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection.
Okumura CY, Hollands A, Tran DN, Olson J, Dahesh S, von Köckritz-Blickwede M, Thienphrapa W, Corle C, Jeung SN, Kotsakis A, Shalwitz RA, Johnson RS, Nizet V. Okumura CY, et al. Among authors: dahesh s. J Mol Med (Berl). 2012 Sep;90(9):1079-89. doi: 10.1007/s00109-012-0882-3. Epub 2012 Feb 28. J Mol Med (Berl). 2012. PMID: 22371073 Free PMC article.
Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria.
Kinjo Y, Illarionov P, Vela JL, Pei B, Girardi E, Li X, Li Y, Imamura M, Kaneko Y, Okawara A, Miyazaki Y, Gómez-Velasco A, Rogers P, Dahesh S, Uchiyama S, Khurana A, Kawahara K, Yesilkaya H, Andrew PW, Wong CH, Kawakami K, Nizet V, Besra GS, Tsuji M, Zajonc DM, Kronenberg M. Kinjo Y, et al. Among authors: dahesh s. Nat Immunol. 2011 Sep 4;12(10):966-74. doi: 10.1038/ni.2096. Nat Immunol. 2011. PMID: 21892173 Free PMC article.
The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design.
van Sorge NM, Cole JN, Kuipers K, Henningham A, Aziz RK, Kasirer-Friede A, Lin L, Berends ETM, Davies MR, Dougan G, Zhang F, Dahesh S, Shaw L, Gin J, Cunningham M, Merriman JA, Hütter J, Lepenies B, Rooijakkers SHM, Malley R, Walker MJ, Shattil SJ, Schlievert PM, Choudhury B, Nizet V. van Sorge NM, et al. Among authors: dahesh s. Cell Host Microbe. 2014 Jun 11;15(6):729-740. doi: 10.1016/j.chom.2014.05.009. Cell Host Microbe. 2014. PMID: 24922575 Free PMC article.
Mutual exclusivity of hyaluronan and hyaluronidase in invasive group A Streptococcus.
Henningham A, Yamaguchi M, Aziz RK, Kuipers K, Buffalo CZ, Dahesh S, Choudhury B, Van Vleet J, Yamaguchi Y, Seymour LM, Ben Zakour NL, He L, Smith HV, Grimwood K, Beatson SA, Ghosh P, Walker MJ, Nizet V, Cole JN. Henningham A, et al. Among authors: dahesh s. J Biol Chem. 2014 Nov 14;289(46):32303-32315. doi: 10.1074/jbc.M114.602847. Epub 2014 Sep 29. J Biol Chem. 2014. PMID: 25266727 Free PMC article.
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