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The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease.
Xiang Z, Thompson AD, Brogan JT, Schulte ML, Melancon BJ, Mi D, Lewis LM, Zou B, Yang L, Morrison R, Santomango T, Byers F, Brewer K, Aldrich JS, Yu H, Dawson ES, Li M, McManus O, Jones CK, Daniels JS, Hopkins CR, Xie XS, Conn PJ, Weaver CD, Lindsley CW. Xiang Z, et al. Among authors: schulte ml. ACS Chem Neurosci. 2011 Dec 21;2(12):730-742. doi: 10.1021/cn200090z. ACS Chem Neurosci. 2011. PMID: 22368764 Free PMC article.
Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354.
Wen W, Young SE, Duvernay MT, Schulte ML, Nance KD, Melancon BJ, Engers J, Locuson CW 2nd, Wood MR, Daniels JS, Wu W, Lindsley CW, Hamm HE, Stauffer SR. Wen W, et al. Among authors: schulte ml. Bioorg Med Chem Lett. 2014 Oct 1;24(19):4708-4713. doi: 10.1016/j.bmcl.2014.08.021. Epub 2014 Aug 15. Bioorg Med Chem Lett. 2014. PMID: 25176330 Free PMC article.
Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds.
Yamada Y, Gilliland K, Xiang Z, Haymer D, Crocker KE, Loch MT, Schulte ML, Rodriguez AL, Niswender CM, Jeffrey Conn P, Lindsley CW, Melancon BJ. Yamada Y, et al. Among authors: schulte ml. Bioorg Med Chem Lett. 2021 Oct 15;50:128342. doi: 10.1016/j.bmcl.2021.128342. Epub 2021 Aug 27. Bioorg Med Chem Lett. 2021. PMID: 34461178
52 results