Jaeger J - Search Results

1

Point mutations in the West Nile virus (Flaviviridae; Flavivirus) RNA-dependent RNA polymerase alter viral fitness in a host-dependent manner in vitro and in vivo.

Van Slyke GA, Ciota AT, Willsey GG, Jaeger J, Shi PY, Kramer LD. Van Slyke GA, et al. Among authors: jaeger j. Virology. 2012 May 25;427(1):18-24. doi: 10.1016/j.virol.2012.01.036. Epub 2012 Feb 23. Virology. 2012. PMID: 22365326 Free PMC article.

2

Residues Arg283, Arg285, and Ile287 in the nucleotide binding pocket of bovine viral diarrhea virus NS5B RNA polymerase affect catalysis and fidelity.

Curti E, Jaeger J. Curti E, et al. Among authors: jaeger j. J Virol. 2013 Jan;87(1):199-207. doi: 10.1128/JVI.06968-11. Epub 2012 Oct 17. J Virol. 2013. PMID: 23077294 Free PMC article.

3

Hydrophobic and charged residues in the C-terminal arm of hepatitis C virus RNA-dependent RNA polymerase regulate initiation and elongation.

Cherry AL, Dennis CA, Baron A, Eisele LE, Thommes PA, Jaeger J. Cherry AL, et al. Among authors: jaeger j. J Virol. 2015 Feb;89(4):2052-63. doi: 10.1128/JVI.01106-14. Epub 2014 Nov 26. J Virol. 2015. PMID: 25428878 Free PMC article.

4

Structural changes in the hydrophobic hinge region adversely affect the activity and fidelity of the I260Q mutator DNA polymerase β.

Gridley CL, Rangarajan S, Firbank S, Dalal S, Sweasy JB, Jaeger J. Gridley CL, et al. Among authors: jaeger j. Biochemistry. 2013 Jun 25;52(25):4422-32. doi: 10.1021/bi301368f. Epub 2013 Jun 12. Biochemistry. 2013. PMID: 23651085 Free PMC article.

5

Hand-holding for retrohoming in a molecular diversity dance.

Jaeger J, Belfort M. Jaeger J, et al. Structure. 2013 Feb 5;21(2):195-6. doi: 10.1016/j.str.2013.01.008. Structure. 2013. PMID: 23394941 Free PMC article.

6

Co-translational myristoylation alters the quaternary structure of HIV-1 Nef in solution.

Dennis CA, Baron A, Grossmann JG, Mazaleyrat S, Harris M, Jaeger J. Dennis CA, et al. Among authors: jaeger j. Proteins. 2005 Sep 1;60(4):658-69. doi: 10.1002/prot.20544. Proteins. 2005. PMID: 16021629

7

The hydrophobic hinge region of rat DNA polymerase beta is critical for substrate binding pocket geometry.

Starcevic D, Dalal S, Jaeger J, Sweasy JB. Starcevic D, et al. Among authors: jaeger j. J Biol Chem. 2005 Aug 5;280(31):28388-93. doi: 10.1074/jbc.M502178200. Epub 2005 May 17. J Biol Chem. 2005. PMID: 15901725 Free article.

8

The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding.

Murphy DL, Kosa J, Jaeger J, Sweasy JB. Murphy DL, et al. Among authors: jaeger j. Biochemistry. 2008 Aug 5;47(31):8048-57. doi: 10.1021/bi702104y. Epub 2008 Jul 11. Biochemistry. 2008. PMID: 18616290 Free PMC article.

9

The I260Q variant of DNA polymerase beta extends mispaired primer termini due to its increased affinity for deoxynucleotide triphosphate substrates.

Dalal S, Starcevic D, Jaeger J, Sweasy JB. Dalal S, et al. Among authors: jaeger j. Biochemistry. 2008 Nov 18;47(46):12118-25. doi: 10.1021/bi8011548. Epub 2008 Oct 21. Biochemistry. 2008. PMID: 18937502 Free PMC article.

10

Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta.

Yamtich J, Starcevic D, Lauper J, Smith E, Shi I, Rangarajan S, Jaeger J, Sweasy JB. Yamtich J, et al. Among authors: jaeger j. Biochemistry. 2010 Mar 23;49(11):2326-34. doi: 10.1021/bi901735a. Biochemistry. 2010. PMID: 20108981 Free PMC article.

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