Xia D - Search Results

1

Evidence for modulatory sites at the lipid-protein interface of the human multidrug transporter P-glycoprotein.

Mandal D, Moitra K, Ghosh D, Xia D, Dey S. Mandal D, et al. Among authors: xia d. Biochemistry. 2012 Apr 3;51(13):2852-66. doi: 10.1021/bi201479k. Epub 2012 Mar 22. Biochemistry. 2012. PMID: 22360349 Free PMC article.

2

The conserved tyrosine residues 401 and 1044 in ATP sites of human P-glycoprotein are critical for ATP binding and hydrolysis: evidence for a conserved subdomain, the A-loop in the ATP-binding cassette.

Kim IW, Peng XH, Sauna ZE, FitzGerald PC, Xia D, Müller M, Nandigama K, Ambudkar SV. Kim IW, et al. Among authors: xia d. Biochemistry. 2006 Jun 20;45(24):7605-16. doi: 10.1021/bi060308o. Biochemistry. 2006. PMID: 16768456

3

Towards understanding the mechanism of action of the multidrug resistance-linked half-ABC transporter ABCG2: a molecular modeling study.

Li YF, Polgar O, Okada M, Esser L, Bates SE, Xia D. Li YF, et al. Among authors: xia d. J Mol Graph Model. 2007 Mar;25(6):837-51. doi: 10.1016/j.jmgm.2006.08.005. Epub 2006 Aug 30. J Mol Graph Model. 2007. PMID: 17027309

4

Mutations define cross-talk between the N-terminal nucleotide-binding domain and transmembrane helix-2 of the yeast multidrug transporter Pdr5: possible conservation of a signaling interface for coupling ATP hydrolysis to drug transport.

Sauna ZE, Bohn SS, Rutledge R, Dougherty MP, Cronin S, May L, Xia D, Ambudkar SV, Golin J. Sauna ZE, et al. Among authors: xia d. J Biol Chem. 2008 Dec 12;283(50):35010-22. doi: 10.1074/jbc.M806446200. Epub 2008 Oct 8. J Biol Chem. 2008. PMID: 18842589 Free PMC article.

5

Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2.

Polgar O, Ierano C, Tamaki A, Stanley B, Ward Y, Xia D, Tarasova N, Robey RW, Bates SE. Polgar O, et al. Among authors: xia d. Biochemistry. 2010 Mar 16;49(10):2235-45. doi: 10.1021/bi902085q. Biochemistry. 2010. PMID: 20088606 Free PMC article.

6

The signaling interface of the yeast multidrug transporter Pdr5 adopts a cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residues.

Ananthaswamy N, Rutledge R, Sauna ZE, Ambudkar SV, Dine E, Nelson E, Xia D, Golin J. Ananthaswamy N, et al. Among authors: xia d. Biochemistry. 2010 Jun 1;49(21):4440-9. doi: 10.1021/bi100394j. Biochemistry. 2010. PMID: 20426485 Free PMC article.

7

Human-Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P-Glycoprotein (ABCB1).

Pluchino KM, Hall MD, Moen JK, Chufan EE, Fetsch PA, Shukla S, Gill DR, Hyde SC, Xia D, Ambudkar SV, Gottesman MM. Pluchino KM, et al. Among authors: xia d. Biochemistry. 2016 Feb 23;55(7):1010-23. doi: 10.1021/acs.biochem.5b01064. Epub 2016 Feb 10. Biochemistry. 2016. PMID: 26820614 Free PMC article.

8

Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle.

Frank GA, Shukla S, Rao P, Borgnia MJ, Bartesaghi A, Merk A, Mobin A, Esser L, Earl LA, Gottesman MM, Xia D, Ambudkar SV, Subramaniam S. Frank GA, et al. Among authors: xia d. Mol Pharmacol. 2016 Jul;90(1):35-41. doi: 10.1124/mol.116.104190. Epub 2016 May 11. Mol Pharmacol. 2016. PMID: 27190212 Free PMC article.

9

The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition.

Gao X, Wen X, Yu C, Esser L, Tsao S, Quinn B, Zhang L, Yu L, Xia D. Gao X, et al. Among authors: xia d. Biochemistry. 2002 Oct 1;41(39):11692-702. doi: 10.1021/bi026252p. Biochemistry. 2002. PMID: 12269811

10

Structural basis for the quinone reduction in the bc1 complex: a comparative analysis of crystal structures of mitochondrial cytochrome bc1 with bound substrate and inhibitors at the Qi site.

Gao X, Wen X, Esser L, Quinn B, Yu L, Yu CA, Xia D. Gao X, et al. Among authors: xia d. Biochemistry. 2003 Aug 5;42(30):9067-80. doi: 10.1021/bi0341814. Biochemistry. 2003. PMID: 12885240

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