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An orally available, small-molecule interferon inhibits viral replication.
Konishi H, Okamoto K, Ohmori Y, Yoshino H, Ohmori H, Ashihara M, Hirata Y, Ohta A, Sakamoto H, Hada N, Katsume A, Kohara M, Morikawa K, Tsukuda T, Shimma N, Foster GR, Alazawi W, Aoki Y, Arisawa M, Sudoh M. Konishi H, et al. Among authors: shimma n. Sci Rep. 2012;2:259. doi: 10.1038/srep00259. Epub 2012 Feb 10. Sci Rep. 2012. PMID: 22355771 Free PMC article.
Host sphingolipid biosynthesis as a target for hepatitis C virus therapy.
Sakamoto H, Okamoto K, Aoki M, Kato H, Katsume A, Ohta A, Tsukuda T, Shimma N, Aoki Y, Arisawa M, Kohara M, Sudoh M. Sakamoto H, et al. Among authors: shimma n. Nat Chem Biol. 2005 Nov;1(6):333-7. doi: 10.1038/nchembio742. Epub 2005 Oct 16. Nat Chem Biol. 2005. PMID: 16408072
Enantioselective synthesis of derivatives and structure-activity relationship study in the development of NA255 as a novel host-targeting anti-HCV agent.
Kawasaki K, Masubuchi M, Hayase T, Komiyama S, Watanabe F, Fukuda H, Murata T, Matsubara Y, Koyama K, Shindoh H, Sakamoto H, Okamato K, Ohta A, Katsume A, Aoki M, Aoki Y, Shimma N, Sudoh M, Tsukuda T. Kawasaki K, et al. Among authors: shimma n. Bioorg Med Chem Lett. 2013 Jan 1;23(1):336-9. doi: 10.1016/j.bmcl.2012.10.083. Epub 2012 Oct 30. Bioorg Med Chem Lett. 2013. PMID: 23164713
Angiogenesis inhibitors identified by cell-based high-throughput screening: synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation.
Hada K, Suda A, Asoh K, Tsukuda T, Hasegawa M, Sato Y, Ogawa K, Kuramoto S, Aoki Y, Shimma N, Ishikawa T, Koyano H. Hada K, et al. Among authors: shimma n. Bioorg Med Chem. 2012 Feb 15;20(4):1442-60. doi: 10.1016/j.bmc.2011.12.058. Epub 2012 Jan 5. Bioorg Med Chem. 2012. PMID: 22269278
Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity.
Ishii N, Harada N, Joseph EW, Ohara K, Miura T, Sakamoto H, Matsuda Y, Tomii Y, Tachibana-Kondo Y, Iikura H, Aoki T, Shimma N, Arisawa M, Sowa Y, Poulikakos PI, Rosen N, Aoki Y, Sakai T. Ishii N, et al. Among authors: shimma n. Cancer Res. 2013 Jul 1;73(13):4050-4060. doi: 10.1158/0008-5472.CAN-12-3937. Epub 2013 May 10. Cancer Res. 2013. PMID: 23667175 Free PMC article.
Identification of a novel inhibitor specific to the fungal chitin synthase. Inhibition of chitin synthase 1 arrests the cell growth, but inhibition of chitin synthase 1 and 2 is lethal in the pathogenic fungus Candida albicans.
Sudoh M, Yamazaki T, Masubuchi K, Taniguchi M, Shimma N, Arisawa M, Yamada-Okabe H. Sudoh M, et al. Among authors: shimma n. J Biol Chem. 2000 Oct 20;275(42):32901-5. doi: 10.1074/jbc.M003634200. J Biol Chem. 2000. PMID: 10930406 Free article.
57 results