Galetin A - Search Results

1

Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data.

Jones HM, Barton HA, Lai Y, Bi YA, Kimoto E, Kempshall S, Tate SC, El-Kattan A, Houston JB, Galetin A, Fenner KS. Jones HM, et al. Among authors: galetin a. Drug Metab Dispos. 2012 May;40(5):1007-17. doi: 10.1124/dmd.111.042994. Epub 2012 Feb 16. Drug Metab Dispos. 2012. PMID: 22344703

2

Development of 4-Pyridoxic Acid PBPK Model to Support Biomarker-Informed Evaluation of OAT1/3 Inhibition and Effect of Chronic Kidney Disease.

Tan SPF, Willemin ME, Snoeys J, Shen H, Rostami-Hodjegan A, Scotcher D, Galetin A. Tan SPF, et al. Among authors: galetin a. Clin Pharmacol Ther. 2023 Dec;114(6):1243-1253. doi: 10.1002/cpt.3029. Epub 2023 Sep 8. Clin Pharmacol Ther. 2023. PMID: 37620246

3

Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug-Drug Interactions in Rats.

Melillo N, Scotcher D, Kenna JG, Green C, Hines CDG, Laitinen I, Hockings PD, Ogungbenro K, Gunwhy ER, Sourbron S, Waterton JC, Schuetz G, Galetin A. Melillo N, et al. Among authors: galetin a. Pharmaceutics. 2023 Mar 10;15(3):896. doi: 10.3390/pharmaceutics15030896. Pharmaceutics. 2023. PMID: 36986758 Free PMC article.

4

Dealing With Variable Drug Exposure Due to Variable Hepatic Metabolism: A Proof-of-Concept Application of Liquid Biopsy in Renal Impairment.

Rostami-Hodjegan A, Al-Majdoub ZM, von Grabowiecki Y, Yee KL, Sahoo S, Breitwieser W, Galetin A, Gibson C, Achour B. Rostami-Hodjegan A, et al. Among authors: galetin a. Clin Pharmacol Ther. 2024 Sep;116(3):814-823. doi: 10.1002/cpt.3291. Epub 2024 May 13. Clin Pharmacol Ther. 2024. PMID: 38738484

5

Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach.

Galetin A, Clarke SE, Houston JB. Galetin A, et al. Drug Metab Dispos. 2002 Dec;30(12):1512-22. doi: 10.1124/dmd.30.12.1512. Drug Metab Dispos. 2002. PMID: 12433827

6

Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human udp-glucuronosyltransferases: evidence for atypical glucuronidation kinetics by UGT2B7.

Stone AN, Mackenzie PI, Galetin A, Houston JB, Miners JO. Stone AN, et al. Among authors: galetin a. Drug Metab Dispos. 2003 Sep;31(9):1086-9. doi: 10.1124/dmd.31.9.1086. Drug Metab Dispos. 2003. PMID: 12920162

7

Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: midazolam, testosterone, and nifedipine.

Galetin A, Clarke SE, Houston JB. Galetin A, et al. Drug Metab Dispos. 2003 Sep;31(9):1108-16. doi: 10.1124/dmd.31.9.1108. Drug Metab Dispos. 2003. PMID: 12920166

8

Progress towards prediction of human pharmacokinetic parameters from in vitro technologies.

Houston JB, Galetin A. Houston JB, et al. Among authors: galetin a. Drug Metab Rev. 2003 Nov;35(4):393-415. doi: 10.1081/dmr-120026870. Drug Metab Rev. 2003. PMID: 14705868 Review.

9

Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid.

Uchaipichat V, Mackenzie PI, Guo XH, Gardner-Stephen D, Galetin A, Houston JB, Miners JO. Uchaipichat V, et al. Among authors: galetin a. Drug Metab Dispos. 2004 Apr;32(4):413-23. doi: 10.1124/dmd.32.4.413. Drug Metab Dispos. 2004. PMID: 15039294

10

Utility of recombinant enzyme kinetics in prediction of human clearance: impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates.

Galetin A, Brown C, Hallifax D, Ito K, Houston JB. Galetin A, et al. Drug Metab Dispos. 2004 Dec;32(12):1411-20. doi: 10.1124/dmd.104.000844. Epub 2004 Sep 1. Drug Metab Dispos. 2004. PMID: 15342470

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