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DRPLA transgenic mouse substrains carrying single copy of full-length mutant human DRPLA gene with variable sizes of expanded CAG repeats exhibit CAG repeat length- and age-dependent changes in behavioral abnormalities and gene expression profiles.
Suzuki K, Zhou J, Sato T, Takao K, Miyagawa T, Oyake M, Yamada M, Takahashi H, Takahashi Y, Goto J, Tsuji S. Suzuki K, et al. Among authors: takao k. Neurobiol Dis. 2012 May;46(2):336-50. doi: 10.1016/j.nbd.2012.01.014. Epub 2012 Feb 8. Neurobiol Dis. 2012. PMID: 22342974
Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory.
Okuda K, Takao K, Watanabe A, Miyakawa T, Mizuguchi M, Tanaka T. Okuda K, et al. Among authors: takao k. PLoS One. 2018 Apr 27;13(4):e0196587. doi: 10.1371/journal.pone.0196587. eCollection 2018. PLoS One. 2018. PMID: 29702698 Free PMC article.
462 results