Ray SS - Search Results

1

Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors.

Cuny GD, Ulyanova NP, Patnaik D, Liu JF, Lin X, Auerbach K, Ray SS, Xian J, Glicksman MA, Stein RL, Higgins JM. Cuny GD, et al. Among authors: ray ss. Bioorg Med Chem Lett. 2012 Mar 1;22(5):2015-9. doi: 10.1016/j.bmcl.2012.01.028. Epub 2012 Jan 28. Bioorg Med Chem Lett. 2012. PMID: 22335895 Free PMC article.

2

Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH.

Kirubakaran S, Gorla SK, Sharling L, Zhang M, Liu X, Ray SS, Macpherson IS, Striepen B, Hedstrom L, Cuny GD. Kirubakaran S, et al. Among authors: ray ss. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1985-8. doi: 10.1016/j.bmcl.2012.01.029. Epub 2012 Jan 24. Bioorg Med Chem Lett. 2012. PMID: 22310229 Free PMC article.

3

Discovery of LRRK2 inhibitors using sequential in silico joint pharmacophore space (JPS) and ensemble docking.

Lang CA, Ray SS, Liu M, Singh AK, Cuny GD. Lang CA, et al. Among authors: ray ss. Bioorg Med Chem Lett. 2015 Jul 1;25(13):2713-9. doi: 10.1016/j.bmcl.2015.04.027. Epub 2015 Apr 16. Bioorg Med Chem Lett. 2015. PMID: 25998502

4

Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant.

Liu M, Kang S, Ray S, Jackson J, Zaitsev AD, Gerber SA, Cuny GD, Glicksman MA. Liu M, et al. Biochemistry. 2011 Nov 1;50(43):9399-408. doi: 10.1021/bi201173d. Epub 2011 Oct 7. Biochemistry. 2011. PMID: 21961647 Free PMC article.

5

The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity.

Ray S, Bender S, Kang S, Lin R, Glicksman MA, Liu M. Ray S, et al. J Biol Chem. 2014 May 9;289(19):13042-53. doi: 10.1074/jbc.M113.537811. Epub 2014 Apr 2. J Biol Chem. 2014. PMID: 24695735 Free PMC article.

6

Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors.

Canning P, Ruan Q, Schwerd T, Hrdinka M, Maki JL, Saleh D, Suebsuwong C, Ray S, Brennan PE, Cuny GD, Uhlig HH, Gyrd-Hansen M, Degterev A, Bullock AN. Canning P, et al. Chem Biol. 2015 Sep 17;22(9):1174-84. doi: 10.1016/j.chembiol.2015.07.017. Epub 2015 Aug 27. Chem Biol. 2015. PMID: 26320862 Free PMC article.

7

Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methods.

Nowak RJ, Cuny GD, Choi S, Lansbury PT, Ray SS. Nowak RJ, et al. Among authors: ray ss. J Med Chem. 2010 Apr 8;53(7):2709-18. doi: 10.1021/jm901062p. J Med Chem. 2010. PMID: 20232802 Free PMC article.

8

Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1.

Maki JL, Smith EE, Teng X, Ray SS, Cuny GD, Degterev A. Maki JL, et al. Among authors: ray ss. Anal Biochem. 2012 Aug 15;427(2):164-74. doi: 10.1016/j.ab.2012.05.019. Epub 2012 May 29. Anal Biochem. 2012. PMID: 22658960 Free PMC article.

9

Type II kinase inhibitors show an unexpected inhibition mode against Parkinson's disease-linked LRRK2 mutant G2019S.

Liu M, Bender SA, Cuny GD, Sherman W, Glicksman M, Ray SS. Liu M, et al. Among authors: ray ss. Biochemistry. 2013 Mar 12;52(10):1725-36. doi: 10.1021/bi3012077. Epub 2013 Mar 1. Biochemistry. 2013. PMID: 23379419 Free PMC article.

10

Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors.

Pytel D, Seyb K, Liu M, Ray SS, Concannon J, Huang M, Cuny GD, Diehl JA, Glicksman MA. Pytel D, et al. Among authors: ray ss. J Biomol Screen. 2014 Aug;19(7):1024-34. doi: 10.1177/1087057114525853. Epub 2014 Mar 5. J Biomol Screen. 2014. PMID: 24598103 Free PMC article.

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