Tyers M - Search Results

1

Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase.

Tang X, Orlicky S, Mittag T, Csizmok V, Pawson T, Forman-Kay JD, Sicheri F, Tyers M. Tang X, et al. Among authors: tyers m. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3287-92. doi: 10.1073/pnas.1116455109. Epub 2012 Feb 10. Proc Natl Acad Sci U S A. 2012. PMID: 22328159 Free PMC article.

2

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase.

Orlicky S, Tang X, Willems A, Tyers M, Sicheri F. Orlicky S, et al. Among authors: tyers m. Cell. 2003 Jan 24;112(2):243-56. doi: 10.1016/s0092-8674(03)00034-5. Cell. 2003. PMID: 12553912 Free article.

3

Genome-wide surveys for phosphorylation-dependent substrates of SCF ubiquitin ligases.

Tang X, Orlicky S, Liu Q, Willems A, Sicheri F, Tyers M. Tang X, et al. Among authors: tyers m. Methods Enzymol. 2005;399:433-58. doi: 10.1016/S0076-6879(05)99030-7. Methods Enzymol. 2005. PMID: 16338374

4

Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity.

Borg M, Mittag T, Pawson T, Tyers M, Forman-Kay JD, Chan HS. Borg M, et al. Among authors: tyers m. Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9650-5. doi: 10.1073/pnas.0702580104. Epub 2007 May 23. Proc Natl Acad Sci U S A. 2007. PMID: 17522259 Free PMC article.

5

Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination.

Tang X, Orlicky S, Lin Z, Willems A, Neculai D, Ceccarelli D, Mercurio F, Shilton BH, Sicheri F, Tyers M. Tang X, et al. Among authors: tyers m. Cell. 2007 Jun 15;129(6):1165-76. doi: 10.1016/j.cell.2007.04.042. Cell. 2007. PMID: 17574027 Free article.

6

Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor.

Mittag T, Orlicky S, Choy WY, Tang X, Lin H, Sicheri F, Kay LE, Tyers M, Forman-Kay JD. Mittag T, et al. Among authors: tyers m. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17772-7. doi: 10.1073/pnas.0809222105. Epub 2008 Nov 13. Proc Natl Acad Sci U S A. 2008. PMID: 19008353 Free PMC article.

7

Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase.

Mittag T, Marsh J, Grishaev A, Orlicky S, Lin H, Sicheri F, Tyers M, Forman-Kay JD. Mittag T, et al. Among authors: tyers m. Structure. 2010 Mar 14;18(4):494-506. doi: 10.1016/j.str.2010.01.020. Structure. 2010. PMID: 20399186 Free PMC article.

8

An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase.

Orlicky S, Tang X, Neduva V, Elowe N, Brown ED, Sicheri F, Tyers M. Orlicky S, et al. Among authors: tyers m. Nat Biotechnol. 2010 Jul;28(7):733-7. doi: 10.1038/nbt.1646. Epub 2010 Jun 27. Nat Biotechnol. 2010. PMID: 20581844 Free PMC article.

9

Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.

Gorelik M, Orlicky S, Sartori MA, Tang X, Marcon E, Kurinov I, Greenblatt JF, Tyers M, Moffat J, Sicheri F, Sidhu SS. Gorelik M, et al. Among authors: tyers m. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3527-32. doi: 10.1073/pnas.1519389113. Epub 2016 Mar 14. Proc Natl Acad Sci U S A. 2016. PMID: 26976582 Free PMC article.

10

An allosteric conduit facilitates dynamic multisite substrate recognition by the SCF^Cdc4 ubiquitin ligase.

Csizmok V, Orlicky S, Cheng J, Song J, Bah A, Delgoshaie N, Lin H, Mittag T, Sicheri F, Chan HS, Tyers M, Forman-Kay JD. Csizmok V, et al. Among authors: tyers m. Nat Commun. 2017 Jan 3;8:13943. doi: 10.1038/ncomms13943. Nat Commun. 2017. PMID: 28045046 Free PMC article.

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