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Melanin-concentrating hormone receptor 1 antagonists. Synthesis and structure-activity relationships of novel 3-(aminomethyl)quinolines.
Kamata M, Yamashita T, Imaeda T, Tanaka T, Masada S, Kamaura M, Kasai S, Hara R, Sasaki S, Takekawa S, Asami A, Kaisho T, Suzuki N, Ashina S, Ogino H, Nakano Y, Nagisa Y, Kato K, Kato K, Ishihara Y. Kamata M, et al. Among authors: tanaka t. J Med Chem. 2012 Mar 8;55(5):2353-66. doi: 10.1021/jm201596h. Epub 2012 Feb 22. J Med Chem. 2012. PMID: 22309223
Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists.
Kamata M, Yamashita T, Imaeda T, Tanaka T, Terauchi J, Miyamoto M, Ora T, Tawada M, Endo S, Takekawa S, Asami A, Suzuki N, Nagisa Y, Nakano Y, Watanabe K, Ogino H, Kato K, Kato K, Ishihara Y. Kamata M, et al. Among authors: tanaka t. Bioorg Med Chem. 2011 Sep 15;19(18):5539-52. doi: 10.1016/j.bmc.2011.07.038. Epub 2011 Jul 26. Bioorg Med Chem. 2011. PMID: 21856163
Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.
Ohashi T, Oguro Y, Tanaka T, Shiokawa Z, Tanaka Y, Shibata S, Sato Y, Yamakawa H, Hattori H, Yamamoto Y, Kondo S, Miyamoto M, Nishihara M, Ishimura Y, Tojo H, Baba A, Sasaki S. Ohashi T, et al. Among authors: tanaka t, tanaka y. Bioorg Med Chem. 2012 Sep 15;20(18):5507-17. doi: 10.1016/j.bmc.2012.07.034. Epub 2012 Jul 27. Bioorg Med Chem. 2012. PMID: 22898254
Synthesis and evaluation of hedgehog signaling inhibitor with novel core system.
Ohashi T, Tanaka Y, Shiokawa Z, Banno H, Tanaka T, Shibata S, Satoh Y, Yamakawa H, Yamamoto Y, Hattori H, Kondo S, Miyamoto M, Tojo H, Baba A, Sasaki S. Ohashi T, et al. Among authors: tanaka t, tanaka y. Bioorg Med Chem. 2015 Aug 1;23(15):4777-4791. doi: 10.1016/j.bmc.2015.05.036. Epub 2015 Jun 3. Bioorg Med Chem. 2015. PMID: 26094943
Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors.
Ito M, Tanaka T, Toita A, Uchiyama N, Kokubo H, Morishita N, Klein MG, Zou H, Murakami M, Kondo M, Sameshima T, Araki S, Endo S, Kawamoto T, Morin GB, Aparicio SA, Nakanishi A, Maezaki H, Imaeda Y. Ito M, et al. Among authors: tanaka t. J Med Chem. 2018 Sep 13;61(17):7710-7728. doi: 10.1021/acs.jmedchem.8b00683. Epub 2018 Aug 20. J Med Chem. 2018. PMID: 30067358
Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays.
Nakao S, Nogami M, Iwatani M, Imaeda T, Ito M, Tanaka T, Tawada M, Endo S, Cary DR, Ohori M, Imaeda Y, Kawamoto T, Aparicio S, Nakanishi A, Araki S. Nakao S, et al. Among authors: tanaka t. Biochem Biophys Res Commun. 2020 Mar 12;523(3):795-801. doi: 10.1016/j.bbrc.2019.12.094. Epub 2020 Jan 15. Biochem Biophys Res Commun. 2020. PMID: 31954521 Free article.
Second-Generation AUTACs for Targeted Autophagic Degradation.
Takahashi D, Ora T, Sasaki S, Ishii N, Tanaka T, Matsuda T, Ikeda M, Moriyama J, Cho N, Nara H, Maezaki H, Kamaura M, Shimokawa K, Arimoto H. Takahashi D, et al. Among authors: tanaka t. J Med Chem. 2023 Sep 14;66(17):12342-12372. doi: 10.1021/acs.jmedchem.3c00861. Epub 2023 Aug 17. J Med Chem. 2023. PMID: 37589438
17,394 results
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