Pai R - Search Results

1

Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys.

Pai R, French D, Ma N, Hotzel K, Plise E, Salphati L, Setchell KD, Ware J, Lauriault V, Schutt L, Hartley D, Dambach D. Pai R, et al. Toxicol Sci. 2012 Apr;126(2):446-56. doi: 10.1093/toxsci/kfs011. Epub 2012 Jan 19. Toxicol Sci. 2012. PMID: 22268002

2

Therapeutic Antibody-Induced Vascular Toxicity Due to Off-Target Activation of Nitric Oxide in Cynomolgus Monkeys.

Pai R, Ma N, Connor AV, Danilenko DM, Tarrant JM, Salvail D, Wong L, Hartley DP, Misner D, Stefanich E, Wu Y, Chen Y, Wang H, Dambach DM. Pai R, et al. Toxicol Sci. 2016 Jun;151(2):245-60. doi: 10.1093/toxsci/kfw037. Epub 2016 Feb 25. Toxicol Sci. 2016. PMID: 26917699

3

Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling.

Pai R, Dunlap D, Qing J, Mohtashemi I, Hotzel K, French DM. Pai R, et al. Cancer Res. 2008 Jul 1;68(13):5086-95. doi: 10.1158/0008-5472.CAN-07-2325. Cancer Res. 2008. PMID: 18593907

4

Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney.

Diaz D, Allamneni K, Tarrant JM, Lewin-Koh SC, Pai R, Dhawan P, Cain GR, Kozlowski C, Hiraragi H, La N, Hartley DP, Ding X, Dean BJ, Bheddah S, Dambach DM. Diaz D, et al. Among authors: pai r. Toxicol Sci. 2012 Jan;125(1):187-95. doi: 10.1093/toxsci/kfr263. Epub 2011 Oct 5. Toxicol Sci. 2012. PMID: 21976371

5

MEK and ERK Kinase Inhibitors Increase Circulating Ceruloplasmin and Cause Green Serum in Rats.

Diaz D, Pai R, Cain G, La N, Dambach D, Schwartz J, Tarrant JM. Diaz D, et al. Among authors: pai r. Toxicol Pathol. 2017 Feb;45(2):353-361. doi: 10.1177/0192623316664590. Epub 2016 Sep 28. Toxicol Pathol. 2017. PMID: 27565173

6

Nonclinical safety assessment of a human interleukin-22FC IG fusion protein demonstrates in vitro to in vivo and cross-species translatability.

Lee DW, Zhong S, Pai R, Rae J, Sukumaran S, Stefanich EG, Lutman J, Doudement E, Wang X, Harder B, Lekkerkerker A, Herman A, Ouyang W, Danilenko DM. Lee DW, et al. Among authors: pai r. Pharmacol Res Perspect. 2018 Nov 15;6(6):e00434. doi: 10.1002/prp2.434. eCollection 2018 Dec. Pharmacol Res Perspect. 2018. PMID: 30464842 Free PMC article.

7

Deoxycholic acid activates beta-catenin signaling pathway and increases colon cell cancer growth and invasiveness.

Pai R, Tarnawski AS, Tran T. Pai R, et al. Mol Biol Cell. 2004 May;15(5):2156-63. doi: 10.1091/mbc.e03-12-0894. Epub 2004 Mar 5. Mol Biol Cell. 2004. PMID: 15004225 Free PMC article.

8

Prostaglandins promote colon cancer cell invasion; signaling by cross-talk between two distinct growth factor receptors.

Pai R, Nakamura T, Moon WS, Tarnawski AS. Pai R, et al. FASEB J. 2003 Sep;17(12):1640-7. doi: 10.1096/fj.02-1011com. FASEB J. 2003. PMID: 12958170

9

Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation.

Pai R, Lin C, Tran T, Tarnawski A. Pai R, et al. Biochem Biophys Res Commun. 2005 Jun 17;331(4):984-92. doi: 10.1016/j.bbrc.2005.03.236. Biochem Biophys Res Commun. 2005. PMID: 15882975

10

Co-expression of cox-2, C-met and beta-catenin in cells forming invasive front of gallbladder cancer.

Moon WS, Park HS, Lee H, Pai R, Tarnawski AS, Kim KR, Jang KY. Moon WS, et al. Among authors: pai r. Cancer Res Treat. 2005 Jun;37(3):171-6. doi: 10.4143/crt.2005.37.3.171. Epub 2005 Jun 30. Cancer Res Treat. 2005. PMID: 19956499 Free PMC article.

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