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p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.
Le NT, Takei Y, Shishido T, Woo CH, Chang E, Heo KS, Lee H, Lu Y, Morrell C, Oikawa M, McClain C, Wang X, Tournier C, Molina CA, Taunton J, Yan C, Fujiwara K, Patterson C, Yang J, Abe J. Le NT, et al. Among authors: taunton j. Circ Res. 2012 Feb 17;110(4):536-50. doi: 10.1161/CIRCRESAHA.111.254730. Epub 2012 Jan 19. Circ Res. 2012. PMID: 22267842 Free PMC article.
A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis.
Le NT, Heo KS, Takei Y, Lee H, Woo CH, Chang E, McClain C, Hurley C, Wang X, Li F, Xu H, Morrell C, Sullivan MA, Cohen MS, Serafimova IM, Taunton J, Fujiwara K, Abe J. Le NT, et al. Among authors: taunton j. Circulation. 2013 Jan 29;127(4):486-99. doi: 10.1161/CIRCULATIONAHA.112.116988. Epub 2012 Dec 14. Circulation. 2013. PMID: 23243209 Free PMC article.
Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals.
Singh MV, Kotla S, Le NT, Ae Ko K, Heo KS, Wang Y, Fujii Y, Thi Vu H, McBeath E, Thomas TN, Jin Gi Y, Tao Y, Medina JL, Taunton J, Carson N, Dogra V, Doyley MM, Tyrell A, Lu W, Qiu X, Stirpe NE, Gates KJ, Hurley C, Fujiwara K, Maggirwar SB, Schifitto G, Abe JI. Singh MV, et al. Among authors: taunton j. Circulation. 2019 Feb 26;139(9):1199-1216. doi: 10.1161/CIRCULATIONAHA.118.036232. Circulation. 2019. PMID: 30586719 Free PMC article. Clinical Trial.
Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2-interacting protein.
Kotla S, Vu HT, Ko KA, Wang Y, Imanishi M, Heo KS, Fujii Y, Thomas TN, Gi YJ, Mazhar H, Paez-Mayorga J, Shin JH, Tao Y, Giancursio CJ, Medina JL, Taunton J, Lusis AJ, Cooke JP, Fujiwara K, Le NT, Abe JI. Kotla S, et al. Among authors: taunton j. JCI Insight. 2019 May 2;4(9):e124867. doi: 10.1172/jci.insight.124867. eCollection 2019 May 2. JCI Insight. 2019. PMID: 31045573 Free PMC article.
MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis.
Abe JI, Ko KA, Kotla S, Wang Y, Paez-Mayorga J, Shin IJ, Imanishi M, Vu HT, Tao Y, Leiva-Juarez MM, Thomas TN, Medina JL, Won JH, Fujii Y, Giancursio CJ, McBeath E, Shin JH, Guzman L, Abe RJ, Taunton J, Mochizuki N, Faubion W, Cooke JP, Fujiwara K, Evans SE, Le NT. Abe JI, et al. Among authors: taunton j. JCI Insight. 2019 Apr 4;4(7):e125570. doi: 10.1172/jci.insight.125570. eCollection 2019 Apr 4. JCI Insight. 2019. PMID: 30944250 Free PMC article.
p90RSK-MAGI1 Module Controls Endothelial Permeability by Post-translational Modifications of MAGI1 and Hippo Pathway.
Abe RJ, Savage H, Imanishi M, Banerjee P, Kotla S, Paez-Mayorga J, Taunton J, Fujiwara K, Won JH, Yusuf SW, Palaskas NL, Banchs J, Lin SH, Schadler KL, Abe JI, Le NT. Abe RJ, et al. Among authors: taunton j. Front Cardiovasc Med. 2020 Nov 13;7:542485. doi: 10.3389/fcvm.2020.542485. eCollection 2020. Front Cardiovasc Med. 2020. PMID: 33304925 Free PMC article.
Corrigendum: p90RSK-MAGI1 Module Controls Endothelial Permeability by Post-translational Modifications of MAGI1 and Hippo Pathway.
Abe RJ, Savage H, Imanishi M, Banerjee P, Kotla S, Paez-Mayorga J, Taunton J, Fujiwara K, Won JH, Yusuf SW, Palaskas NL, Banchs J, Lin SH, Schadler KL, Abe JI, Le NT. Abe RJ, et al. Among authors: taunton j. Front Cardiovasc Med. 2021 Feb 19;8:663486. doi: 10.3389/fcvm.2021.663486. eCollection 2021. Front Cardiovasc Med. 2021. PMID: 33681312 Free PMC article.
Evidence for direct regulation of myocardial Na+/H+ exchanger isoform 1 phosphorylation and activity by 90-kDa ribosomal S6 kinase (RSK): effects of the novel and specific RSK inhibitor fmk on responses to alpha1-adrenergic stimulation.
Cuello F, Snabaitis AK, Cohen MS, Taunton J, Avkiran M. Cuello F, et al. Among authors: taunton j. Mol Pharmacol. 2007 Mar;71(3):799-806. doi: 10.1124/mol.106.029900. Epub 2006 Dec 1. Mol Pharmacol. 2007. PMID: 17142297
258 results