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Global transcriptome analysis of rat hypothalamic arcuate nucleus demonstrates reversal of hypothalamic gliosis following surgically and diet induced weight loss.
Barkholt P, Rigbolt KTG, Falkenhahn M, Hübschle T, Schwahn U, Fernandez-Cachon ML, Schmidt T, Theis S, Hansen HH, Hay-Schmidt A, Pedersen PJ, Vrang N, Jelsing J. Barkholt P, et al. Among authors: fernandez cachon ml. Sci Rep. 2019 Nov 6;9(1):16161. doi: 10.1038/s41598-019-52257-8. Sci Rep. 2019. PMID: 31695063 Free PMC article.
Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control.
Fernandez-Cachon ML, Pedersen SL, Rigbolt KT, Zhang C, Fabricius K, Hansen HH, Elster L, Fink LN, Schäfer M, Rhee NA, Langholz E, Wandall E, Friis SU, Vilmann P, Kristiansen VB, Schmidt C, Schreiter K, Breitschopf K, Hübschle T, Jorsal T, Vilsbøll T, Schmidt T, Theis S, Knop FK, Larsen PJ, Jelsing J. Fernandez-Cachon ML, et al. Peptides. 2018 Mar;101:32-43. doi: 10.1016/j.peptides.2017.12.024. Epub 2017 Dec 28. Peptides. 2018. PMID: 29289697 Clinical Trial.