Cheng J - Search Results

1

Design, synthesis, and structure-activity relationship studies of conformationally restricted mutilin 14-carbamates.

Fu L, Liu X, Ling C, Cheng J, Guo X, He H, Ding S, Yang Y. Fu L, et al. Among authors: cheng j. Bioorg Med Chem Lett. 2012 Jan 15;22(2):814-9. doi: 10.1016/j.bmcl.2011.12.063. Epub 2011 Dec 20. Bioorg Med Chem Lett. 2012. PMID: 22209487

2

Evaluation of the antipsychotic effect of bi-acetylated l-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligand.

Guo Y, Zhang H, Chen X, Cai W, Cheng J, Yang Y, Jin G, Zhen X. Guo Y, et al. Among authors: cheng j. Schizophr Res. 2009 Nov;115(1):41-9. doi: 10.1016/j.schres.2009.08.002. Epub 2009 Sep 9. Schizophr Res. 2009. PMID: 19744833

3

Enantioselective total synthesis of (-)-(S)-stepholidine.

Cheng JJ, Yang YS. Cheng JJ, et al. J Org Chem. 2009 Dec 4;74(23):9225-8. doi: 10.1021/jo9020826. J Org Chem. 2009. PMID: 19950885

4

Design, synthesis and evaluation of novel HDAC inhibitors as potential antitumor agents.

Cheng J, Qin J, Guo S, Qiu H, Zhong Y. Cheng J, et al. Bioorg Med Chem Lett. 2014 Oct 1;24(19):4768-4772. doi: 10.1016/j.bmcl.2014.06.080. Epub 2014 Jul 5. Bioorg Med Chem Lett. 2014. PMID: 25182565

5

Design and Discovery of Functionally Selective Serotonin 2C (5-HT_2C) Receptor Agonists.

Cheng J, McCorvy JD, Giguere PM, Zhu H, Kenakin T, Roth BL, Kozikowski AP. Cheng J, et al. J Med Chem. 2016 Nov 10;59(21):9866-9880. doi: 10.1021/acs.jmedchem.6b01194. Epub 2016 Oct 25. J Med Chem. 2016. PMID: 27726356

6

Optimization of P2Y₁₂ Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties.

Kong D, Xue T, Guo B, Cheng J, Liu S, Wei J, Lu Z, Liu H, Gong G, Lan T, Hu W, Yang Y. Kong D, et al. Among authors: cheng j. J Med Chem. 2019 Mar 28;62(6):3088-3106. doi: 10.1021/acs.jmedchem.8b01971. Epub 2019 Mar 19. J Med Chem. 2019. PMID: 30843696

7

Structure-Based Design of Dual-Acting Compounds Targeting Adenosine A_2A Receptor and Histone Deacetylase as Novel Tumor Immunotherapeutic Agents.

Yan W, Ling L, Wu Y, Yang K, Liu R, Zhang J, Zhao S, Zhong G, Zhao S, Jiang H, Xie C, Cheng J. Yan W, et al. Among authors: cheng j. J Med Chem. 2021 Nov 25;64(22):16573-16597. doi: 10.1021/acs.jmedchem.1c01155. Epub 2021 Nov 16. J Med Chem. 2021. PMID: 34783558

8

2-Phenylcyclopropylmethylamine Derivatives as Dopamine D₂ Receptor Partial Agonists: Design, Synthesis, and Biological Evaluation.

Yan W, Fan L, Yu J, Liu R, Wang H, Tan L, Wang S, Cheng J. Yan W, et al. Among authors: cheng j. J Med Chem. 2021 Dec 9;64(23):17239-17258. doi: 10.1021/acs.jmedchem.1c01327. Epub 2021 Nov 19. J Med Chem. 2021. PMID: 34797051

9

Design and Synthesis of Triazole-Containing HDAC Inhibitors That Induce Antitumor Effects and Immune Response.

Sun N, Yang K, Yan W, Yao M, Yu C, Duan W, Gu X, Guo D, Jiang H, Xie C, Cheng J. Sun N, et al. Among authors: cheng j. J Med Chem. 2023 Apr 13;66(7):4802-4826. doi: 10.1021/acs.jmedchem.2c01985. Epub 2023 Mar 19. J Med Chem. 2023. PMID: 36934335

10

Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.

Cheng J, Giguère PM, Onajole OK, Lv W, Gaisin A, Gunosewoyo H, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Vistoli G, Wetsel WC, Roth BL, Kozikowski AP. Cheng J, et al. J Med Chem. 2015 Feb 26;58(4):1992-2002. doi: 10.1021/jm5019274. Epub 2015 Feb 10. J Med Chem. 2015. PMID: 25633969 Free PMC article.

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