Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice.
Liangpunsakul S, Rahmini Y, Ross RA, Zhao Z, Xu Y, Crabb DW.
Liangpunsakul S, et al. Among authors: ross ra.
Am J Physiol Gastrointest Liver Physiol. 2012 Mar 1;302(5):G515-23. doi: 10.1152/ajpgi.00455.2011. Epub 2011 Dec 22.
Am J Physiol Gastrointest Liver Physiol. 2012.
PMID: 22194417
Free PMC article.
Our previous data showed the inhibitory effect of ethanol on AMP-activated protein kinase phosphorylation, which appears to be mediated, in part, through increased levels of hepatic ceramide and activation of protein phosphatase 2A (Liangpunsakul S, Sozio MS, Shin E, Zhao Z, Xu Y …
Our previous data showed the inhibitory effect of ethanol on AMP-activated protein kinase phosphorylation, which appears to be mediated, in …