Jayaraman M - Search Results

1

Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments.

Jayaraman M, Kodali R, Sahoo B, Thakur AK, Mayasundari A, Mishra R, Peterson CB, Wetzel R. Jayaraman M, et al. J Mol Biol. 2012 Feb 3;415(5):881-99. doi: 10.1016/j.jmb.2011.12.010. Epub 2011 Dec 9. J Mol Biol. 2012. PMID: 22178474 Free PMC article.

2

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism.

Thakur AK, Jayaraman M, Mishra R, Thakur M, Chellgren VM, Byeon IJ, Anjum DH, Kodali R, Creamer TP, Conway JF, Gronenborn AM, Wetzel R. Thakur AK, et al. Among authors: jayaraman m. Nat Struct Mol Biol. 2009 Apr;16(4):380-9. doi: 10.1038/nsmb.1570. Epub 2009 Mar 8. Nat Struct Mol Biol. 2009. PMID: 19270701 Free PMC article.

3

The impact of ataxin-1-like histidine insertions on polyglutamine aggregation.

Jayaraman M, Kodali R, Wetzel R. Jayaraman M, et al. Protein Eng Des Sel. 2009 Aug;22(8):469-78. doi: 10.1093/protein/gzp023. Epub 2009 Jun 18. Protein Eng Des Sel. 2009. PMID: 19541676 Free PMC article.

4

Assays for studying nucleated aggregation of polyglutamine proteins.

Jayaraman M, Thakur AK, Kar K, Kodali R, Wetzel R. Jayaraman M, et al. Methods. 2011 Mar;53(3):246-54. doi: 10.1016/j.ymeth.2011.01.001. Epub 2011 Jan 11. Methods. 2011. PMID: 21232603 Free PMC article.

5

Critical nucleus size for disease-related polyglutamine aggregation is repeat-length dependent.

Kar K, Jayaraman M, Sahoo B, Kodali R, Wetzel R. Kar K, et al. Among authors: jayaraman m. Nat Struct Mol Biol. 2011 Mar;18(3):328-36. doi: 10.1038/nsmb.1992. Epub 2011 Feb 13. Nat Struct Mol Biol. 2011. PMID: 21317897 Free PMC article.

6

The aggregation-enhancing huntingtin N-terminus is helical in amyloid fibrils.

Sivanandam VN, Jayaraman M, Hoop CL, Kodali R, Wetzel R, van der Wel PC. Sivanandam VN, et al. Among authors: jayaraman m. J Am Chem Soc. 2011 Mar 30;133(12):4558-66. doi: 10.1021/ja110715f. Epub 2011 Mar 7. J Am Chem Soc. 2011. PMID: 21381744 Free PMC article.

7

Inhibiting the nucleation of amyloid structure in a huntingtin fragment by targeting α-helix-rich oligomeric intermediates.

Mishra R, Jayaraman M, Roland BP, Landrum E, Fullam T, Kodali R, Thakur AK, Arduini I, Wetzel R. Mishra R, et al. Among authors: jayaraman m. J Mol Biol. 2012 Feb 3;415(5):900-17. doi: 10.1016/j.jmb.2011.12.011. Epub 2011 Dec 9. J Mol Biol. 2012. PMID: 22178478 Free PMC article.

8

Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and properties.

Jayaraman M, Mishra R, Kodali R, Thakur AK, Koharudin LM, Gronenborn AM, Wetzel R. Jayaraman M, et al. Biochemistry. 2012 Apr 3;51(13):2706-16. doi: 10.1021/bi3000929. Epub 2012 Mar 20. Biochemistry. 2012. PMID: 22432740 Free PMC article.

9

Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions.

Crick SL, Jayaraman M, Frieden C, Wetzel R, Pappu RV. Crick SL, et al. Among authors: jayaraman m. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16764-9. doi: 10.1073/pnas.0608175103. Epub 2006 Oct 30. Proc Natl Acad Sci U S A. 2006. PMID: 17075061 Free PMC article.

10

Aggregation and conformational studies on a pentapeptide derivative.

Sambasivam D, Liu CW, Jayaraman M, Malar EJ, Rajadas J. Sambasivam D, et al. Among authors: jayaraman m. Biochim Biophys Acta. 2008 Nov;1784(11):1659-67. doi: 10.1016/j.bbapap.2008.07.015. Epub 2008 Aug 7. Biochim Biophys Acta. 2008. PMID: 18775521

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