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Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1.
Wu AL, Kolumam G, Stawicki S, Chen Y, Li J, Zavala-Solorio J, Phamluong K, Feng B, Li L, Marsters S, Kates L, van Bruggen N, Leabman M, Wong A, West D, Stern H, Luis E, Kim HS, Yansura D, Peterson AS, Filvaroff E, Wu Y, Sonoda J. Wu AL, et al. Among authors: kolumam g. Sci Transl Med. 2011 Dec 14;3(113):113ra126. doi: 10.1126/scitranslmed.3002669. Sci Transl Med. 2011. PMID: 22174314
Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels.
Lipari MT, Li W, Moran P, Kong-Beltran M, Sai T, Lai J, Lin SJ, Kolumam G, Zavala-Solorio J, Izrael-Tomasevic A, Arnott D, Wang J, Peterson AS, Kirchhofer D. Lipari MT, et al. Among authors: kolumam g. J Biol Chem. 2012 Dec 21;287(52):43482-91. doi: 10.1074/jbc.M112.380618. Epub 2012 Nov 7. J Biol Chem. 2012. PMID: 23135270 Free PMC article.
Targeting oxidized LDL improves insulin sensitivity and immune cell function in obese Rhesus macaques.
Li S, Kievit P, Robertson AK, Kolumam G, Li X, von Wachenfeldt K, Valfridsson C, Bullens S, Messaoudi I, Bader L, Cowan KJ, Kamath A, van Bruggen N, Bunting S, Frendéus B, Grove KL. Li S, et al. Among authors: kolumam g. Mol Metab. 2013 Jun 11;2(3):256-69. doi: 10.1016/j.molmet.2013.06.001. eCollection 2013. Mol Metab. 2013. PMID: 24049738 Free PMC article.
Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.
Mukund S, Shang Y, Clarke HJ, Madjidi A, Corn JE, Kates L, Kolumam G, Chiang V, Luis E, Murray J, Zhang Y, Hötzel I, Koth CM, Allan BB. Mukund S, et al. Among authors: kolumam g. J Biol Chem. 2013 Dec 13;288(50):36168-78. doi: 10.1074/jbc.M113.496984. Epub 2013 Nov 4. J Biol Chem. 2013. PMID: 24189067 Free PMC article.
Systemic VEGF-A neutralization ameliorates diet-induced metabolic dysfunction.
Wu LE, Meoli CC, Mangiafico SP, Fazakerley DJ, Cogger VC, Mohamad M, Pant H, Kang MJ, Powter E, Burchfield JG, Xirouchaki CE, Mikolaizak AS, Stöckli J, Kolumam G, van Bruggen N, Gamble JR, Le Couteur DG, Cooney GJ, Andrikopoulos S, James DE. Wu LE, et al. Among authors: kolumam g. Diabetes. 2014 Aug;63(8):2656-67. doi: 10.2337/db13-1665. Epub 2014 Apr 2. Diabetes. 2014. PMID: 24696450
Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of α-Cell Mass.
Solloway MJ, Madjidi A, Gu C, Eastham-Anderson J, Clarke HJ, Kljavin N, Zavala-Solorio J, Kates L, Friedman B, Brauer M, Wang J, Fiehn O, Kolumam G, Stern H, Lowe JB, Peterson AS, Allan BB. Solloway MJ, et al. Among authors: kolumam g. Cell Rep. 2015 Jul 21;12(3):495-510. doi: 10.1016/j.celrep.2015.06.034. Epub 2015 Jul 9. Cell Rep. 2015. PMID: 26166562 Free article.
46 results