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The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Randomised Study.
Thomas JL, McGee KC, Hossain A, Perkins GD, Gordon AC, Young D, McAuley D, Singer M, Lall R, Kramaric T, Lord JM, Whitehouse T, Mur LAJ; STRESS-L. collaborators. Thomas JL, et al. Intensive Care Med Exp. 2025 Jan 22;13(1):9. doi: 10.1186/s40635-024-00708-6. Intensive Care Med Exp. 2025. PMID: 39841388 Free PMC article.
Effective cancer immunotherapy combining mRNA-encoded bispecific antibodies that induce polyclonal T cell engagement and PD-L1-dependent 4-1BB costimulation.
Hangiu O, Navarro R, Frago S, Rubio-Pérez L, Tapia-Galisteo A, Díez-Alonso L, Gómez-Rosel M, Silva-Pilipich N, Vanrell L, Smerdou C, Howard KA, Sanz L, Álvarez-Vallina L, Compte M. Hangiu O, et al. Among authors: howard ka. Front Immunol. 2025 Jan 6;15:1494206. doi: 10.3389/fimmu.2024.1494206. eCollection 2024. Front Immunol. 2025. PMID: 39835115 Free PMC article.
Long term health outcomes in people with diabetes 12 months after hospitalisation with COVID-19 in the UK: a prospective cohort study.
Gharibzadeh S, Routen A, Razieh C, Zaccardi F, Lawson C, Gillies C, Heller S, Davies M, Atkins H, Bain SC, Lone NL, Poinasamy K, Peto T, Robertson E, Young B, Johnston D, Quint J, Valabhji J, Ismail K, Marks M, Horsley A, Docherty A, Harrison E, Chalmers J, Ho LP, Raman B, Brightling C, Elneima O, Evans R, Greening N, Harris VC, Houchen-Wolloff L, Sereno M, Shikotra A, Singapuri A, Wain L, Langenberg C, Dennis J, Petrie J, Sattar N, Leavy O, Richardson M, Saunders RM, McArdle A, McASuley H, Yates T, Khunti K; PHOSP-COVID Study Collaborative Group. Gharibzadeh S, et al. EClinicalMedicine. 2024 Dec 27;79:103005. doi: 10.1016/j.eclinm.2024.103005. eCollection 2025 Jan. EClinicalMedicine. 2024. PMID: 39834716 Free PMC article.
The time for regionalised vaccine manufacturing has arrived.
Dzau V, Hatchett R, Bishen S, Kaseya J, Barbosa J, Fezoua F, Kristensen F; RVMC Secretariat. Dzau V, et al. Lancet. 2025 Jan 14:S0140-6736(25)00050-9. doi: 10.1016/S0140-6736(25)00050-9. Online ahead of print. Lancet. 2025. PMID: 39824196 No abstract available.
Satellite microglia: marker of traumatic brain injury and regulator of neuronal excitability.
Feichtenbiner AB, Sytsma K, O'Boyle RP, Mittenzwei R, Maioli H, Scherpelz KP, Child DD, Li N, Ariza Torres J, Keene L, Kirkland A, Howard K, Latimer C, Keene CD, Ransom C, Nolan AL. Feichtenbiner AB, et al. Among authors: howard k. J Neuroinflammation. 2025 Jan 16;22(1):9. doi: 10.1186/s12974-024-03328-9. J Neuroinflammation. 2025. PMID: 39819341 Free PMC article.
Targeted Next-Generation Sequencing of Cell-Free DNA to Detect MYC-Immunoglobulin Translocation and Epstein-Barr Virus DNA in Plasma of Burkitt Lymphoma Patients in East Africa.
Chamba C, Jennings D, Shungu R, Christopher H, Josephat E, Howard K, Dreau H, Burns A, Mawalla W, Mapendo P, Mnango L, Legason I, Elias E, Achola C, Cutts A, Balandya E, Schuh A; AI-REAL Consortium. Chamba C, et al. Among authors: howard k. JCO Glob Oncol. 2025 Jan;11:e2400210. doi: 10.1200/GO.24.00210. Epub 2025 Jan 9. JCO Glob Oncol. 2025. PMID: 39787450
Multimodal cell-free DNA whole-genome TAPS is sensitive and reveals specific cancer signals.
Vavoulis DV, Cutts A, Thota N, Brown J, Sugar R, Rueda A, Ardalan A, Howard K, Matos Santo F, Sannasiddappa T, Miller B, Ash S, Liu Y, Song CX, Nicholson BD, Dreau H, Tregidgo C, Schuh A. Vavoulis DV, et al. Among authors: howard k. Nat Commun. 2025 Jan 8;16(1):430. doi: 10.1038/s41467-024-55428-y. Nat Commun. 2025. PMID: 39779727 Free PMC article.
1,255 results