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The beta subunit determines the ion selectivity of the GABAA receptor.
Jensen ML, Timmermann DB, Johansen TH, Schousboe A, Varming T, Ahring PK. Jensen ML, et al. Among authors: ahring pk. J Biol Chem. 2002 Nov 1;277(44):41438-47. doi: 10.1074/jbc.M205645200. Epub 2002 Aug 12. J Biol Chem. 2002. PMID: 12177063 Free article.
Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.
Hald H, Naur P, Pickering DS, Sprogøe D, Madsen U, Timmermann DB, Ahring PK, Liljefors T, Schousboe A, Egebjerg J, Gajhede M, Kastrup JS. Hald H, et al. Among authors: ahring pk. J Biol Chem. 2007 Aug 31;282(35):25726-36. doi: 10.1074/jbc.M700137200. Epub 2007 Jun 20. J Biol Chem. 2007. PMID: 17581823 Free article.
An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo.
Timmermann DB, Grønlien JH, Kohlhaas KL, Nielsen EØ, Dam E, Jørgensen TD, Ahring PK, Peters D, Holst D, Christensen JK, Malysz J, Briggs CA, Gopalakrishnan M, Olsen GM. Timmermann DB, et al. Among authors: ahring pk. J Pharmacol Exp Ther. 2007 Oct;323(1):294-307. doi: 10.1124/jpet.107.120436. Epub 2007 Jul 11. J Pharmacol Exp Ther. 2007. PMID: 17625074
Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory and neuropathic pain.
Munro G, Lopez-Garcia JA, Rivera-Arconada I, Erichsen HK, Nielsen EØ, Larsen JS, Ahring PK, Mirza NR. Munro G, et al. Among authors: ahring pk. J Pharmacol Exp Ther. 2008 Dec;327(3):969-81. doi: 10.1124/jpet.108.144568. Epub 2008 Sep 12. J Pharmacol Exp Ther. 2008. PMID: 18791060
NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy.
Mirza NR, Larsen JS, Mathiasen C, Jacobsen TA, Munro G, Erichsen HK, Nielsen AN, Troelsen KB, Nielsen EØ, Ahring PK. Mirza NR, et al. Among authors: ahring pk. J Pharmacol Exp Ther. 2008 Dec;327(3):954-68. doi: 10.1124/jpet.108.138859. Epub 2008 Sep 12. J Pharmacol Exp Ther. 2008. PMID: 18791063
80 results