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Low-dose penile SIVmac251 exposure of rhesus macaques infected with adenovirus type 5 (Ad5) and then immunized with a replication-defective Ad5-based SIV gag/pol/nef vaccine recapitulates the results of the phase IIb step trial of a similar HIV-1 vaccine.
Qureshi H, Ma ZM, Huang Y, Hodge G, Thomas MA, DiPasquale J, DeSilva V, Fritts L, Bett AJ, Casimiro DR, Shiver JW, Robert-Guroff M, Robertson MN, McChesney MB, Gilbert PB, Miller CJ. Qureshi H, et al. Among authors: mcchesney mb. J Virol. 2012 Feb;86(4):2239-50. doi: 10.1128/JVI.06175-11. Epub 2011 Dec 7. J Virol. 2012. PMID: 22156519 Free PMC article. Clinical Trial.
The Toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaques.
Wang Y, Abel K, Lantz K, Krieg AM, McChesney MB, Miller CJ. Wang Y, et al. Among authors: mcchesney mb. J Virol. 2005 Nov;79(22):14355-70. doi: 10.1128/JVI.79.22.14355-14370.2005. J Virol. 2005. PMID: 16254370 Free PMC article.
With minimal systemic T-cell expansion, CD8+ T Cells mediate protection of rhesus macaques immunized with attenuated simian-human immunodeficiency virus SHIV89.6 from vaginal challenge with simian immunodeficiency virus.
Genescà M, Skinner PJ, Hong JJ, Li J, Lu D, McChesney MB, Miller CJ. Genescà M, et al. Among authors: mcchesney mb. J Virol. 2008 Nov;82(22):11181-96. doi: 10.1128/JVI.01433-08. Epub 2008 Sep 10. J Virol. 2008. PMID: 18787003 Free PMC article.
89 results