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Triple knockdown of CD11a, CD49d, and PSGL1 in T cells reduces CAR-T cell toxicity but preserves activity against solid tumors in mice.
Wang H, Wu Z, Cui D, Bian L, Zheng Z, Zhu J, Geng H, Sun Z, Pan Y, Shi Y, Yi Q, Song Z, Li Y, Shen K, Li Y, Shen W, Yan H, Hao R, Sun M, Zhang S, Zhang C, Jin H, Zhai B. Wang H, et al. Among authors: cui d. Sci Transl Med. 2025 Jan 22;17(782):eadl6432. doi: 10.1126/scitranslmed.adl6432. Epub 2025 Jan 22. Sci Transl Med. 2025. PMID: 39841806
3,109 results