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Page 1
Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold.
Kurata H, Kusumi K, Otsuki K, Suzuki R, Kurono M, Tokuda N, Takada Y, Shioya H, Mizuno H, Komiya T, Ono T, Hagiya H, Minami M, Nakade S, Habashita H. Kurata H, et al. Among authors: habashita h. Bioorg Med Chem Lett. 2012 Jan 1;22(1):144-8. doi: 10.1016/j.bmcl.2011.11.048. Epub 2011 Nov 20. Bioorg Med Chem Lett. 2012. PMID: 22153936
Discovery of S1P agonists with a dihydronaphthalene scaffold.
Kurata H, Kusumi K, Otsuki K, Suzuki R, Kurono M, Takada Y, Shioya H, Komiya T, Mizuno H, Ono T, Hagiya H, Minami M, Nakade S, Habashita H. Kurata H, et al. Among authors: habashita h. Bioorg Med Chem Lett. 2011 Jul 1;21(13):3885-9. doi: 10.1016/j.bmcl.2011.05.029. Epub 2011 May 15. Bioorg Med Chem Lett. 2011. PMID: 21641216
Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of Autoimmune Diseases.
Kurata H, Kusumi K, Otsuki K, Suzuki R, Kurono M, Komiya T, Hagiya H, Mizuno H, Shioya H, Ono T, Takada Y, Maeda T, Matsunaga N, Kondo T, Tominaga S, Nunoya KI, Kiyoshi H, Komeno M, Nakade S, Habashita H. Kurata H, et al. Among authors: habashita h. J Med Chem. 2017 Dec 14;60(23):9508-9530. doi: 10.1021/acs.jmedchem.7b00785. Epub 2017 Nov 21. J Med Chem. 2017. PMID: 29120624
Efficacy and immunomodulatory actions of ONO-4641, a novel selective agonist for sphingosine 1-phosphate receptors 1 and 5, in preclinical models of multiple sclerosis.
Komiya T, Sato K, Shioya H, Inagaki Y, Hagiya H, Kozaki R, Imai M, Takada Y, Maeda T, Kurata H, Kurono M, Suzuki R, Otsuki K, Habashita H, Nakade S. Komiya T, et al. Among authors: habashita h. Clin Exp Immunol. 2013 Jan;171(1):54-62. doi: 10.1111/j.1365-2249.2012.04669.x. Clin Exp Immunol. 2013. PMID: 23199323 Free PMC article.
Discovery of a new chemical lead for a matrix metalloproteinase inhibitor.
Ikura M, Nakatani S, Yamamoto S, Habashita H, Sugiura T, Takahashi K, Ogawa K, Ohno H, Nakai H, Toda M. Ikura M, et al. Among authors: habashita h. Bioorg Med Chem. 2006 Jun 15;14(12):4241-52. doi: 10.1016/j.bmc.2006.01.059. Epub 2006 Feb 14. Bioorg Med Chem. 2006. PMID: 16481176
Discovery of orally available spirodiketopiperazine-based CCR5 antagonists.
Nishizawa R, Nishiyama T, Hisaichi K, Hirai K, Habashita H, Takaoka Y, Tada H, Sagawa K, Shibayama S, Maeda K, Mitsuya H, Nakai H, Fukushima D, Toda M. Nishizawa R, et al. Among authors: habashita h. Bioorg Med Chem. 2010 Jul 15;18(14):5208-23. doi: 10.1016/j.bmc.2010.05.057. Epub 2010 May 25. Bioorg Med Chem. 2010. PMID: 20542438 Free PMC article.
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