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129,752 results

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Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice.
Goonasekera SA, Hammer K, Auger-Messier M, Bodi I, Chen X, Zhang H, Reiken S, Elrod JW, Correll RN, York AJ, Sargent MA, Hofmann F, Moosmang S, Marks AR, Houser SR, Bers DM, Molkentin JD. Goonasekera SA, et al. Among authors: zhang h. J Clin Invest. 2012 Jan;122(1):280-90. doi: 10.1172/JCI58227. Epub 2011 Dec 1. J Clin Invest. 2012. PMID: 22133878 Free PMC article.
STIM1 elevation in the heart results in aberrant Ca²⁺ handling and cardiomyopathy.
Correll RN, Goonasekera SA, van Berlo JH, Burr AR, Accornero F, Zhang H, Makarewich CA, York AJ, Sargent MA, Chen X, Houser SR, Molkentin JD. Correll RN, et al. Among authors: zhang h. J Mol Cell Cardiol. 2015 Oct;87:38-47. doi: 10.1016/j.yjmcc.2015.07.032. Epub 2015 Aug 1. J Mol Cell Cardiol. 2015. PMID: 26241845 Free PMC article.
Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction.
Makarewich CA, Zhang H, Davis J, Correll RN, Trappanese DM, Hoffman NE, Troupes CD, Berretta RM, Kubo H, Madesh M, Chen X, Gao E, Molkentin JD, Houser SR. Makarewich CA, et al. Among authors: zhang h. Circ Res. 2014 Aug 29;115(6):567-580. doi: 10.1161/CIRCRESAHA.115.303831. Epub 2014 Jul 21. Circ Res. 2014. PMID: 25047165 Free PMC article.
Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy.
Chen X, Nakayama H, Zhang X, Ai X, Harris DM, Tang M, Zhang H, Szeto C, Stockbower K, Berretta RM, Eckhart AD, Koch WJ, Molkentin JD, Houser SR. Chen X, et al. Among authors: zhang x, zhang h. J Mol Cell Cardiol. 2011 Mar;50(3):460-70. doi: 10.1016/j.yjmcc.2010.11.012. Epub 2010 Nov 25. J Mol Cell Cardiol. 2011. PMID: 21111744 Free PMC article.
Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias.
Zhang X, Ai X, Nakayama H, Chen B, Harris DM, Tang M, Xie Y, Szeto C, Li Y, Li Y, Zhang H, Eckhart AD, Koch WJ, Molkentin JD, Chen X. Zhang X, et al. Among authors: zhang h. Basic Res Cardiol. 2016 Jan;111(1):4. doi: 10.1007/s00395-015-0523-4. Epub 2015 Nov 26. Basic Res Cardiol. 2016. PMID: 26611208 Free PMC article.
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