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Cytotoxicity of quinolones toward eukaryotic cells. Identification of topoisomerase II as the primary cellular target for the quinolone CP-115,953 in yeast.
Elsea SH, Osheroff N, Nitiss JL. Elsea SH, et al. Among authors: osheroff n. J Biol Chem. 1992 Jul 5;267(19):13150-3. J Biol Chem. 1992. PMID: 1320012 Free article.
R., Moynihan, M., Sutcliffe, J. A., and Osheroff, N. (1991) J. Biol. Chem. 266, 14585-14592). Although the quinolone is highly toxic to mammalian cells in culture, its mechanism of cytotoxic action is not known. ...
R., Moynihan, M., Sutcliffe, J. A., and Osheroff, N. (1991) J. Biol. Chem. 266, 14585-14592). Although the quinolone is highly …
Effects of antineoplastic drugs on the post-strand-passage DNA cleavage/religation equilibrium of topoisomerase II.
Robinson MJ, Osheroff N. Robinson MJ, et al. Among authors: osheroff n. Biochemistry. 1991 Feb 19;30(7):1807-13. doi: 10.1021/bi00221a012. Biochemistry. 1991. PMID: 1847075
Since previous studies demonstrated that antineoplastic drugs stabilize the pre-strand-passage cleavage complex of topoisomerase II by impairing the enzyme's ability to religate cleaved DNA [Osheroff, N. (1989) Biochemistry 28, 6157-6160; Robinson, M.J., & Os …
Since previous studies demonstrated that antineoplastic drugs stabilize the pre-strand-passage cleavage complex of topoisomerase II by impai …
Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzyme-mediated DNA religation by 4'-(9-acridinylamino)methanesulfon-m-anisidide.
Robinson MJ, Osheroff N. Robinson MJ, et al. Among authors: osheroff n. Biochemistry. 1990 Mar 13;29(10):2511-5. doi: 10.1021/bi00462a012. Biochemistry. 1990. PMID: 2159323
This result is similar to that previously reported for the effects of etoposide on the activity of the Drosophila enzyme [Osheroff, N. (1989) Biochemistry 28, 6157-6160]. Thus, it appears that structurally disparate classes of topoisomerase II targeted antineoplasti …
This result is similar to that previously reported for the effects of etoposide on the activity of the Drosophila enzyme [Osheroff, …
Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide.
Osheroff N. Osheroff N. Biochemistry. 1989 Jul 25;28(15):6157-60. doi: 10.1021/bi00441a005. Biochemistry. 1989. PMID: 2551366
By employing a topoisomerase II mediated DNA religation assay [Osheroff, N. & Zechiedrich, E.L. (1987) Biochemistry 26, 4303-4309], etoposide was found to stabilize the enzyme-DNA cleavage complex (at least in part) by inhibiting the enzyme's ability to religate …
By employing a topoisomerase II mediated DNA religation assay [Osheroff, N. & Zechiedrich, E.L. (1987) Biochemistry 26, 43 …
Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate.
Zechiedrich EL, Christiansen K, Andersen AH, Westergaard O, Osheroff N. Zechiedrich EL, et al. Among authors: osheroff n. Biochemistry. 1989 Jul 25;28(15):6229-36. doi: 10.1021/bi00441a014. Biochemistry. 1989. PMID: 2551367
Finally, by use of a novel religation assay [Osheroff, N., & Zechiedrich, E. L. (1987) Biochemistry 26, 4303-4309], it was shown that nicked DNA is an obligatory kinetic intermediate in the topoisomerase II mediated reunion of double-stranded breaks. ...
Finally, by use of a novel religation assay [Osheroff, N., & Zechiedrich, E. L. (1987) Biochemistry 26, 4303-4309], it was …
245 results