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Distinct relations among plasma concentrations required for different pharmacological effects in oxycodone, morphine, and fentanyl.
Nakamura A, Hasegawa M, Ito H, Minami K, Koike K, Habu-Tomita N, Nanba K, Hamaguchi K, Noshi E, Hashimoto H, Nishino I, Okabayashi Y, Koyabu K, Kihara T, Iwamoto Y, Inoue Y, Narita M, Suzuki T, Kato A. Nakamura A, et al. Among authors: suzuki t. J Pain Palliat Care Pharmacother. 2011;25(4):318-34. doi: 10.3109/15360288.2011.620689. J Pain Palliat Care Pharmacother. 2011. PMID: 22126163
Morphine, oxycodone, and fentanyl exhibit different analgesic profiles in mouse pain models.
Minami K, Hasegawa M, Ito H, Nakamura A, Tomii T, Matsumoto M, Orita S, Matsushima S, Miyoshi T, Masuno K, Torii M, Koike K, Shimada S, Kanemasa T, Kihara T, Narita M, Suzuki T, Kato A. Minami K, et al. Among authors: suzuki t. J Pharmacol Sci. 2009 Sep;111(1):60-72. doi: 10.1254/jphs.09139fp. Epub 2009 Sep 4. J Pharmacol Sci. 2009. PMID: 19729873 Free article.
[Difference in tolerance to anti-hyperalgesic effect and its molecular mechanisms between chronic treatment with morphine, fentanyl and oxycodone in a chronic pain-like state].
Satoshi I, Narita M, Ozeki A, Nakamura A, Hashimoto S, Narita M, Kuzumaki N, Uezono Y, Suzuki T. Satoshi I, et al. Among authors: suzuki t. Nihon Shinkei Seishin Yakurigaku Zasshi. 2008 Nov;28(5-6):169-76. Nihon Shinkei Seishin Yakurigaku Zasshi. 2008. PMID: 19108502 Review. Japanese.
G protein-gated inwardly rectifying potassium (KIR3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites.
Nakamura A, Fujita M, Ono H, Hongo Y, Kanbara T, Ogawa K, Morioka Y, Nishiyori A, Shibasaki M, Mori T, Suzuki T, Sakaguchi G, Kato A, Hasegawa M. Nakamura A, et al. Among authors: suzuki t. Br J Pharmacol. 2014 Jan;171(1):253-64. doi: 10.1111/bph.12441. Br J Pharmacol. 2014. PMID: 24117458 Free PMC article.
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