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In vitro and in vivo characterisation of Lu AF64280, a novel, brain penetrant phosphodiesterase (PDE) 2A inhibitor: potential relevance to cognitive deficits in schizophrenia.
Redrobe JP, Jørgensen M, Christoffersen CT, Montezinho LP, Bastlund JF, Carnerup M, Bundgaard C, Lerdrup L, Plath N. Redrobe JP, et al. Psychopharmacology (Berl). 2014 Aug;231(16):3151-67. doi: 10.1007/s00213-014-3492-7. Epub 2014 Mar 1. Psychopharmacology (Berl). 2014. PMID: 24577516
Discovery and optimization of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration.
Eskildsen J, Redrobe JP, Sams AG, Dekermendjian K, Laursen M, Boll JB, Papke RL, Bundgaard C, Frederiksen K, Bastlund JF. Eskildsen J, et al. Among authors: redrobe jp. Bioorg Med Chem Lett. 2014 Jan 1;24(1):288-93. doi: 10.1016/j.bmcl.2013.11.022. Epub 2013 Nov 20. Bioorg Med Chem Lett. 2014. PMID: 24291041
Investigating the long-term effect of subchronic phencyclidine-treatment on novel object recognition and the association between the gut microbiota and behavior in the animal model of schizophrenia.
Pyndt Jørgensen B, Krych L, Pedersen TB, Plath N, Redrobe JP, Hansen AK, Nielsen DS, Pedersen CS, Larsen C, Sørensen DB. Pyndt Jørgensen B, et al. Among authors: redrobe jp. Physiol Behav. 2015 Mar 15;141:32-9. doi: 10.1016/j.physbeh.2014.12.042. Epub 2014 Dec 26. Physiol Behav. 2015. PMID: 25545766
47 results