Fraser NJ - Search Results

1

Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity.

Biffen M, Matsui H, Edwards S, Leishman AJ, Eiho K, Holness E, Satterthwaite G, Doyle I, Wada H, Fraser NJ, Hawkins SL, Aoki M, Tomizawa H, Benjamin AD, Takaku H, McInally T, Murray CM. Biffen M, et al. Among authors: fraser nj. Br J Pharmacol. 2012 May;166(2):573-86. doi: 10.1111/j.1476-5381.2011.01790.x. Br J Pharmacol. 2012. PMID: 22122192 Free PMC article.

2

A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation.

Marshall JD, Heeke DS, Rao E, Maynard SK, Hornigold D, McCrae C, Fraser N, Tovchigrechko A, Yu L, Williams N, King S, Cooper ME, Hajjar AM, Woo JC. Marshall JD, et al. PLoS One. 2016 Oct 13;11(10):e0164632. doi: 10.1371/journal.pone.0164632. eCollection 2016. PLoS One. 2016. PMID: 27736941 Free PMC article.

3

Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors.

Browning C, Beresford I, Fraser N, Giles H. Browning C, et al. Br J Pharmacol. 2000 Mar;129(5):877-86. doi: 10.1038/sj.bjp.0703130. Br J Pharmacol. 2000. PMID: 10696085 Free PMC article.

4

Euodenine A: a small-molecule agonist of human TLR4.

Neve JE, Wijesekera HP, Duffy S, Jenkins ID, Ripper JA, Teague SJ, Campitelli M, Garavelas A, Nikolakopoulos G, Le PV, de A Leone P, Pham NB, Shelton P, Fraser N, Carroll AR, Avery VM, McCrae C, Williams N, Quinn RJ. Neve JE, et al. J Med Chem. 2014 Feb 27;57(4):1252-75. doi: 10.1021/jm401321v. Epub 2014 Feb 7. J Med Chem. 2014. PMID: 24471857

5

Development of a homogeneous MAP kinase reporter gene screen for the identification of agonists and antagonists at the CXCR1 chemokine receptor.

Rees S, Martin DP, Scott SV, Brown SH, Fraser N, O'Shaughnessy C, Beresford IJ. Rees S, et al. J Biomol Screen. 2001 Feb;6(1):19-27. doi: 10.1177/108705710100600104. J Biomol Screen. 2001. PMID: 11679162

6

A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor.

Stables J, Green A, Marshall F, Fraser N, Knight E, Sautel M, Milligan G, Lee M, Rees S. Stables J, et al. Anal Biochem. 1997 Oct 1;252(1):115-26. doi: 10.1006/abio.1997.2308. Anal Biochem. 1997. PMID: 9324949

7

The CGRP receptor can couple via pertussis toxin sensitive and insensitive G proteins.

Main MJ, Brown J, Brown S, Fraser NJ, Foord SM. Main MJ, et al. Among authors: fraser nj. FEBS Lett. 1998 Dec 11;441(1):6-10. doi: 10.1016/s0014-5793(98)01507-5. FEBS Lett. 1998. PMID: 9877154 Free article.

8

Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product.

Christopoulos G, Perry KJ, Morfis M, Tilakaratne N, Gao Y, Fraser NJ, Main MJ, Foord SM, Sexton PM. Christopoulos G, et al. Among authors: fraser nj. Mol Pharmacol. 1999 Jul;56(1):235-42. doi: 10.1124/mol.56.1.235. Mol Pharmacol. 1999. PMID: 10385705

9

The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin receptor-like receptor.

Fraser NJ, Wise A, Brown J, McLatchie LM, Main MJ, Foord SM. Fraser NJ, et al. Mol Pharmacol. 1999 Jun;55(6):1054-9. doi: 10.1124/mol.55.6.1054. Mol Pharmacol. 1999. PMID: 10347248

10

Calcium sensing properties of the GABA(B) receptor.

Wise A, Green A, Main MJ, Wilson R, Fraser N, Marshall FH. Wise A, et al. Neuropharmacology. 1999 Nov;38(11):1647-56. doi: 10.1016/s0028-3908(99)00119-7. Neuropharmacology. 1999. PMID: 10587080

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