Laufer S - Search Results

1

Mechanistic role of p38 MAPK in gastric cancer dissemination in a rodent model peritoneal metastasis.

Graziosi L, Mencarelli A, Santorelli C, Renga B, Cipriani S, Cavazzoni E, Palladino G, Laufer S, Burnet M, Donini A, Fiorucci S. Graziosi L, et al. Among authors: laufer s. Eur J Pharmacol. 2012 Jan 15;674(2-3):143-52. doi: 10.1016/j.ejphar.2011.11.015. Epub 2011 Nov 19. Eur J Pharmacol. 2012. PMID: 22119383

2

Novel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscle.

Munoz L, Ramsay EE, Manetsch M, Ge Q, Peifer C, Laufer S, Ammit AJ. Munoz L, et al. Among authors: laufer s. Eur J Pharmacol. 2010 Jun 10;635(1-3):212-8. doi: 10.1016/j.ejphar.2010.02.037. Epub 2010 Mar 9. Eur J Pharmacol. 2010. PMID: 20226180

3

Design and Synthesis of Highly Selective Brain Penetrant p38α Mitogen-Activated Protein Kinase Inhibitors.

Tormählen NM, Martorelli M, Kuhn A, Maier F, Guezguez J, Burnet M, Albrecht W, Laufer SA, Koch P. Tormählen NM, et al. J Med Chem. 2022 Jan 27;65(2):1225-1242. doi: 10.1021/acs.jmedchem.0c01773. Epub 2021 May 11. J Med Chem. 2022. PMID: 33974419

4

Selective Inhibitors of Janus Kinase 3 Modify Responses to Lipopolysaccharides by Increasing the Interleukin-10-to-Tumor Necrosis Factor α Ratio.

Laux J, Martorelli M, Späth N, Maier F, Burnet M, Laufer SA. Laux J, et al. ACS Pharmacol Transl Sci. 2023 May 18;6(6):892-906. doi: 10.1021/acsptsci.3c00043. eCollection 2023 Jun 9. ACS Pharmacol Transl Sci. 2023. PMID: 37325444 Free PMC article.

5

Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation.

Saulle E, Riccioni R, Coppola S, Parolini I, Diverio D, Riti V, Mariani G, Laufer S, Sargiacomo M, Testa U. Saulle E, et al. Among authors: laufer s. Br J Haematol. 2009 May;145(3):399-411. doi: 10.1111/j.1365-2141.2009.07627.x. Epub 2009 Feb 24. Br J Haematol. 2009. PMID: 19245429 Free article.

6

The decrease of cell membrane fluidity by the non-steroidal anti-inflammatory drug Licofelone inhibits epidermal growth factor receptor signalling and triggers apoptosis in HCA-7 colon cancer cells.

Tavolari S, Munarini A, Storci G, Laufer S, Chieco P, Guarnieri T. Tavolari S, et al. Among authors: laufer s. Cancer Lett. 2012 Aug 28;321(2):187-94. doi: 10.1016/j.canlet.2012.02.003. Epub 2012 Feb 14. Cancer Lett. 2012. PMID: 22343320

7

p38 MAPK inhibitors: a patent review (2012 - 2013).

Bühler S, Laufer SA. Bühler S, et al. Among authors: laufer sa. Expert Opin Ther Pat. 2014 May;24(5):535-54. doi: 10.1517/13543776.2014.894977. Epub 2014 Mar 10. Expert Opin Ther Pat. 2014. PMID: 24611721 Review.

8

Impact of p38 MAP Kinase Inhibitors on LPS-Induced Release of TNF-α in Whole Blood and Primary Cells from Different Species.

Fehr S, Unger A, Schaeffeler E, Herrmann S, Laufer S, Schwab M, Albrecht W. Fehr S, et al. Among authors: laufer s. Cell Physiol Biochem. 2015;36(6):2237-49. doi: 10.1159/000430188. Epub 2015 Jul 24. Cell Physiol Biochem. 2015. PMID: 26279429 Free article.

9

Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation.

Astolfi A, Kudolo M, Brea J, Manni G, Manfroni G, Palazzotti D, Sabatini S, Cecchetti F, Felicetti T, Cannalire R, Massari S, Tabarrini O, Loza MI, Fallarino F, Cecchetti V, Laufer SA, Barreca ML. Astolfi A, et al. Among authors: laufer sa. Eur J Med Chem. 2019 Nov 15;182:111624. doi: 10.1016/j.ejmech.2019.111624. Epub 2019 Aug 16. Eur J Med Chem. 2019. PMID: 31445234

10

Selective targeting of the αC and DFG-out pocket in p38 MAPK.

Röhm S, Schröder M, Dwyer JE, Widdowson CS, Chaikuad A, Berger BT, Joerger AC, Krämer A, Harbig J, Dauch D, Kudolo M, Laufer S, Bagley MC, Knapp S. Röhm S, et al. Among authors: laufer s. Eur J Med Chem. 2020 Dec 15;208:112721. doi: 10.1016/j.ejmech.2020.112721. Epub 2020 Aug 20. Eur J Med Chem. 2020. PMID: 33035818

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