Al-Abed Y - Search Results

1

Macrophage migration inhibitory factor mediates hypoxia-induced pulmonary hypertension.

Zhang Y, Talwar A, Tsang D, Bruchfeld A, Sadoughi A, Hu M, Omonuwa K, Cheng KF, Al-Abed Y, Miller EJ. Zhang Y, et al. Mol Med. 2012 Mar 27;18(1):215-23. doi: 10.2119/molmed.2011.00094. Mol Med. 2012. PMID: 22113497 Free PMC article.

2

Biochemical and mutational investigations of the enzymatic activity of macrophage migration inhibitory factor.

Bendrat K, Al-Abed Y, Callaway DJ, Peng T, Calandra T, Metz CN, Bucala R. Bendrat K, et al. Biochemistry. 1997 Dec 9;36(49):15356-62. doi: 10.1021/bi971153a. Biochemistry. 1997. PMID: 9398265

3

Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites.

Senter PD, Al-Abed Y, Metz CN, Benigni F, Mitchell RA, Chesney J, Han J, Gartner CG, Nelson SD, Todaro GJ, Bucala R. Senter PD, et al. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):144-9. doi: 10.1073/pnas.011569399. Epub 2002 Jan 2. Proc Natl Acad Sci U S A. 2002. PMID: 11773615 Free PMC article.

4

Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis.

Wang H, Liao H, Ochani M, Justiniani M, Lin X, Yang L, Al-Abed Y, Wang H, Metz C, Miller EJ, Tracey KJ, Ulloa L. Wang H, et al. Nat Med. 2004 Nov;10(11):1216-21. doi: 10.1038/nm1124. Epub 2004 Oct 24. Nat Med. 2004. PMID: 15502843 Free article.

5

Alpha-chemokine receptor blockade reduces high mobility group box 1 protein-induced lung inflammation and injury and improves survival in sepsis.

Lin X, Yang H, Sakuragi T, Hu M, Mantell LL, Hayashi S, Al-Abed Y, Tracey KJ, Ulloa L, Miller EJ. Lin X, et al. Am J Physiol Lung Cell Mol Physiol. 2005 Oct;289(4):L583-90. doi: 10.1152/ajplung.00091.2005. Epub 2005 Jun 3. Am J Physiol Lung Cell Mol Physiol. 2005. PMID: 15937067 Free article.

6

ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis.

Al-Abed Y, Dabideen D, Aljabari B, Valster A, Messmer D, Ochani M, Tanovic M, Ochani K, Bacher M, Nicoletti F, Metz C, Pavlov VA, Miller EJ, Tracey KJ. Al-Abed Y, et al. J Biol Chem. 2005 Nov 4;280(44):36541-4. doi: 10.1074/jbc.C500243200. Epub 2005 Aug 22. J Biol Chem. 2005. PMID: 16115897 Free article.

7

Macrophage migration inhibitory factor within the alveolar spaces induces changes in the heart during late experimental sepsis.

Lin X, Sakuragi T, Metz CN, Ojamaa K, Skopicki HA, Wang P, Al-Abed Y, Miller EJ. Lin X, et al. Shock. 2005 Dec;24(6):556-63. doi: 10.1097/01.shk.0000183238.70374.a8. Shock. 2005. PMID: 16317387

8

Critical modifications of the ISO-1 scaffold improve its potent inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity.

Cheng KF, Al-Abed Y. Cheng KF, et al. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3376-9. doi: 10.1016/j.bmcl.2006.04.038. Epub 2006 May 6. Bioorg Med Chem Lett. 2006. PMID: 16682188

9

Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis.

Pavlov VA, Ochani M, Yang LH, Gallowitsch-Puerta M, Ochani K, Lin X, Levi J, Parrish WR, Rosas-Ballina M, Czura CJ, Larosa GJ, Miller EJ, Tracey KJ, Al-Abed Y. Pavlov VA, et al. Crit Care Med. 2007 Apr;35(4):1139-44. doi: 10.1097/01.CCM.0000259381.56526.96. Crit Care Med. 2007. PMID: 17334244

10

Lung-derived macrophage migration inhibitory factor in sepsis induces cardio-circulatory depression.

Sakuragi T, Lin X, Metz CN, Ojamaa K, Kohn N, Al-Abed Y, Miller EJ. Sakuragi T, et al. Surg Infect (Larchmt). 2007 Feb;8(1):29-40. doi: 10.1089/sur.2006.031. Surg Infect (Larchmt). 2007. PMID: 17381395 Free PMC article.

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