Hasegawa K - Search Results

1

A new series of the SMTP plasminogen modulator with a phenylglycine-based side chain.

Koide H, Narasaki R, Hasegawa K, Nishimura N, Hasumi K. Koide H, et al. Among authors: hasegawa k. J Antibiot (Tokyo). 2012 Feb;65(2):91-3. doi: 10.1038/ja.2011.108. Epub 2011 Nov 23. J Antibiot (Tokyo). 2012. PMID: 22108677 No abstract available.

2

Isolation and absolute configuration of SMTP-0, a simplest congener of the SMTP family nonlysine-analog plasminogen modulators.

Hasumi K, Hasegawa K, Kitano Y. Hasumi K, et al. Among authors: hasegawa k. J Antibiot (Tokyo). 2007 Jul;60(7):463-8. doi: 10.1038/ja.2007.60. J Antibiot (Tokyo). 2007. PMID: 17721006

3

Microbial conversion of L-ascorbic acid to L-erythroascorbic acid.

Kyotani D, Hasegawa K, Ohishi H, Wu W, Wang L, Hasumi K. Kyotani D, et al. Among authors: hasegawa k. Biosci Biotechnol Biochem. 2009 Apr 23;73(4):954-6. doi: 10.1271/bbb.80785. Epub 2009 Apr 7. Biosci Biotechnol Biochem. 2009. PMID: 19352023 Free article.

4

Structure-activity relationships of 11 new congeners of the SMTP plasminogen modulator.

Hasegawa K, Koide H, Hu W, Nishimura N, Narasaki R, Kitano Y, Hasumi K. Hasegawa K, et al. J Antibiot (Tokyo). 2010 Oct;63(10):589-93. doi: 10.1038/ja.2010.101. Epub 2010 Sep 15. J Antibiot (Tokyo). 2010. PMID: 20842143

5

A new series of the SMTP plasminogen modulators with a phenylamine-based side chain.

Koide H, Hasegawa K, Nishimura N, Narasaki R, Hasumi K. Koide H, et al. Among authors: hasegawa k. J Antibiot (Tokyo). 2012 Jul;65(7):361-7. doi: 10.1038/ja.2012.29. Epub 2012 Apr 18. J Antibiot (Tokyo). 2012. PMID: 22511228

6

Pre-SMTP, a key precursor for the biosynthesis of the SMTP plasminogen modulators.

Nishimura Y, Suzuki E, Hasegawa K, Nishimura N, Kitano Y, Hasumi K. Nishimura Y, et al. Among authors: hasegawa k. J Antibiot (Tokyo). 2012 Sep;65(9):483-5. doi: 10.1038/ja.2012.47. Epub 2012 Jun 20. J Antibiot (Tokyo). 2012. PMID: 22714026 No abstract available.

7

SMTP-7, a novel small-molecule thrombolytic for ischemic stroke: a study in rodents and primates.

Sawada H, Nishimura N, Suzuki E, Zhuang J, Hasegawa K, Takamatsu H, Honda K, Hasumi K. Sawada H, et al. Among authors: hasegawa k. J Cereb Blood Flow Metab. 2014 Feb;34(2):235-41. doi: 10.1038/jcbfm.2013.191. Epub 2013 Nov 6. J Cereb Blood Flow Metab. 2014. PMID: 24192639 Free PMC article.

8

Confirmation of the absolute configuration of Stachybotrin C using single-crystal X-ray diffraction analysis of its 4-bromobenzyl ether derivative.

Kuroda Y, Hasegawa K, Noguchi K, Chiba K, Hasumi K, Kitano Y. Kuroda Y, et al. Among authors: hasegawa k. J Antibiot (Tokyo). 2018 Jun;71(6):584-591. doi: 10.1038/s41429-018-0042-2. Epub 2018 Mar 19. J Antibiot (Tokyo). 2018. PMID: 29555967

9

Efficacy of SMTP-7, a small-molecule anti-inflammatory thrombolytic, in embolic stroke in monkeys.

Suzuki E, Nishimura N, Yoshikawa T, Kunikiyo Y, Hasegawa K, Hasumi K. Suzuki E, et al. Among authors: hasegawa k. Pharmacol Res Perspect. 2018 Dec 5;6(6):e00448. doi: 10.1002/prp2.448. eCollection 2018 Dec. Pharmacol Res Perspect. 2018. PMID: 30546909 Free PMC article.

10

A first-in-human study of the anti-inflammatory profibrinolytic TMS-007, an SMTP family triprenyl phenol.

Moritoyo T, Nishimura N, Hasegawa K, Ishii S, Kirihara K, Takata M, Svensson AK, Umeda-Kameyama Y, Kawarasaki S, Ihara R, Sakanaka C, Wakabayashi Y, Niizuma K, Tominaga T, Yamazaki T, Hasumi K. Moritoyo T, et al. Among authors: hasegawa k. Br J Clin Pharmacol. 2023 Jun;89(6):1809-1819. doi: 10.1111/bcp.15651. Epub 2023 Jan 11. Br J Clin Pharmacol. 2023. PMID: 36562925 Free article. Clinical Trial.

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