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A novel functional haplotype in the human GNAS gene alters Galphas expression, responsiveness to beta-adrenoceptor stimulation, and peri-operative cardiac performance.
Frey UH, Adamzik M, Kottenberg-Assenmacher E, Jakob H, Manthey I, Broecker-Preuss M, Bergmann L, Heusch G, Siffert W, Peters J, Leineweber K. Frey UH, et al. Among authors: leineweber k. Eur Heart J. 2009 Jun;30(11):1402-10. doi: 10.1093/eurheartj/ehn572. Epub 2009 Jan 10. Eur Heart J. 2009. PMID: 19136681
In patients chronically treated with metoprolol, the demand of inotropic catecholamine support after coronary artery bypass grafting is determined by the Arg389Gly-beta 1-adrenoceptor polymorphism.
Leineweber K, Bogedain P, Wolf C, Wagner S, Weber M, Jakob HG, Heusch G, Philipp T, Brodde OE. Leineweber K, et al. Naunyn Schmiedebergs Arch Pharmacol. 2007 Jul;375(5):303-9. doi: 10.1007/s00210-007-0166-6. Epub 2007 Jun 1. Naunyn Schmiedebergs Arch Pharmacol. 2007. PMID: 17541557
72 results