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Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression.
Adams AB, Durham MM, Kean L, Shirasugi N, Ha J, Williams MA, Rees PA, Cheung MC, Mittelstaedt S, Bingaman AW, Archer DR, Pearson TC, Waller EK, Larsen CP. Adams AB, et al. Among authors: larsen cp. J Immunol. 2001 Jul 15;167(2):1103-11. doi: 10.4049/jimmunol.167.2.1103. J Immunol. 2001. PMID: 11441122
A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation.
Kean LS, Durham MM, Adams AB, Hsu LL, Perry JR, Dillehay D, Pearson TC, Waller EK, Larsen CP, Archer DR. Kean LS, et al. Among authors: larsen cp. Blood. 2002 Mar 1;99(5):1840-9. doi: 10.1182/blood.v99.5.1840. Blood. 2002. PMID: 11861303 Free article.
Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression.
Kean LS, Adams AB, Strobert E, Hendrix R, Gangappa S, Jones TR, Shirasugi N, Rigby MR, Hamby K, Jiang J, Bello H, Anderson D, Cardona K, Durham MM, Pearson TC, Larsen CP. Kean LS, et al. Among authors: larsen cp. Am J Transplant. 2007 Feb;7(2):320-35. doi: 10.1111/j.1600-6143.2006.01622.x. Am J Transplant. 2007. PMID: 17241112 Free article.
399 results