McHugh RJ - Search Results

1

Pyrazolone-based anaplastic lymphoma kinase (ALK) inhibitors: control of selectivity by a benzyloxy group.

Tripathy R, McHugh RJ, Ghose AK, Ott GR, Angeles TS, Albom MS, Huang Z, Aimone LD, Cheng M, Dorsey BD. Tripathy R, et al. Among authors: mchugh rj. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7261-4. doi: 10.1016/j.bmcl.2011.10.055. Epub 2011 Oct 20. Bioorg Med Chem Lett. 2011. PMID: 22061645

2

Discovery of a potent inhibitor of anaplastic lymphoma kinase with in vivo antitumor activity.

Ott GR, Tripathy R, Cheng M, McHugh R, Anzalone AV, Underiner TL, Curry MA, Quail MR, Lu L, Wan W, Angeles TS, Albom MS, Aimone LD, Ator MA, Ruggeri BA, Dorsey BD. Ott GR, et al. ACS Med Chem Lett. 2010 Sep 1;1(9):493-8. doi: 10.1021/ml100158s. eCollection 2010 Dec 9. ACS Med Chem Lett. 2010. PMID: 24900237 Free PMC article.

3

Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors.

Weinberg LR, Albom MS, Angeles TS, Husten J, Lisko JG, McHugh RJ, Milkiewicz KL, Murthy S, Ott GR, Theroff JP, Tripathy R, Underiner TL, Zificsak CA, Dorsey BD. Weinberg LR, et al. Among authors: mchugh rj. Bioorg Med Chem Lett. 2011 Jan 1;21(1):164-7. doi: 10.1016/j.bmcl.2010.11.045. Epub 2010 Nov 11. Bioorg Med Chem Lett. 2011. PMID: 21123062

4

Strategies to mitigate the bioactivation of 2-anilino-7-aryl-pyrrolo[2,1-f][1,2,4]triazines: identification of orally bioavailable, efficacious ALK inhibitors.

Mesaros EF, Thieu TV, Wells GJ, Zificsak CA, Wagner JC, Breslin HJ, Tripathy R, Diebold JL, McHugh RJ, Wohler AT, Quail MR, Wan W, Lu L, Huang Z, Albom MS, Angeles TS, Wells-Knecht KJ, Aimone LD, Cheng M, Ator MA, Ott GR, Dorsey BD. Mesaros EF, et al. Among authors: mchugh rj. J Med Chem. 2012 Jan 12;55(1):115-25. doi: 10.1021/jm2010767. Epub 2011 Dec 29. J Med Chem. 2012. PMID: 22141319

5

Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT₆ receptor antagonist showing activity in rat social recognition test.

Tripathy R, McHugh RJ, Bacon ER, Salvino JM, Morton GC, Aimone LD, Huang Z, Mathiasen JR, DiCamillo A, Huffman MJ, McKenna BA, Kopec K, Lu LD, Qian J, Angeles TS, Connors T, Spais C, Holskin B, Duzic E, Schaffhauser H, Rossé GC. Tripathy R, et al. Among authors: mchugh rj. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1421-6. doi: 10.1016/j.bmcl.2011.12.026. Epub 2011 Dec 13. Bioorg Med Chem Lett. 2012. PMID: 22226656

6

The synthesis of symmetrical and unsymmetrical P1/P1' cyclic ureas as HIV protease inhibitors.

Patel M, Kaltenbach RF 3rd, Nugiel DA, McHugh RJ Jr, Jadhav PK, Bacheler LT, Cordova BC, Klabe RM, Erickson-Viitanen S, Garber S, Reid C, Seitz SP. Patel M, et al. Among authors: mchugh rj jr. Bioorg Med Chem Lett. 1998 May 5;8(9):1077-82. doi: 10.1016/s0960-894x(98)00175-9. Bioorg Med Chem Lett. 1998. PMID: 9871711

7

Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVA).

Patel M, McHugh RJ Jr, Cordova BC, Klabe RM, Erickson-Viitanen S, Trainor GL, Ko SS. Patel M, et al. Among authors: mchugh rj jr. Bioorg Med Chem Lett. 1999 Nov 15;9(22):3221-4. doi: 10.1016/s0960-894x(99)00565-x. Bioorg Med Chem Lett. 1999. PMID: 10576692

8

Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors.

Patel M, McHugh RJ Jr, Cordova BC, Klabe RM, Erickson-Viitanen S, Trainor GL, Rodgers JD. Patel M, et al. Among authors: mchugh rj jr. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1729-31. doi: 10.1016/s0960-894x(00)00321-8. Bioorg Med Chem Lett. 2000. PMID: 10937734

9

Synthesis and evaluation of analogs of Efavirenz (SUSTIVA) as HIV-1 reverse transcriptase inhibitors.

Patel M, Ko SS, McHugh RJ Jr, Markwalder JA, Srivastava AS, Cordova BC, Klabe RM, Erickson-Viitanen S, Trainor GL, Seitz SP. Patel M, et al. Among authors: mchugh rj jr. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2805-10. doi: 10.1016/s0960-894x(99)00486-2. Bioorg Med Chem Lett. 1999. PMID: 10522695

10

Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors.

Patel M, McHugh RJ Jr, Cordova BC, Klabe RM, Bacheler LT, Erickson-Viitanen S, Rodgers JD. Patel M, et al. Among authors: mchugh rj jr. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1943-5. doi: 10.1016/s0960-894x(01)00331-6. Bioorg Med Chem Lett. 2001. PMID: 11459666

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