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Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach.
Xin Z, Peng H, Zhang A, Talreja T, Kumaravel G, Xu L, Rohde E, Jung MY, Shackett MN, Kocisko D, Chollate S, Dunah AW, Snodgrass-Belt PA, Arnold HM, Taveras AG, Rhodes KJ, Scannevin RH. Xin Z, et al. Among authors: zhang a. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7277-80. doi: 10.1016/j.bmcl.2011.10.047. Epub 2011 Oct 19. Bioorg Med Chem Lett. 2011. PMID: 22061640
1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 positive allosteric modulators for the treatment of psychosis.
Zhang L, Brodney MA, Candler J, Doran AC, Duplantier AJ, Efremov IV, Evrard E, Kraus K, Ganong AH, Haas JA, Hanks AN, Jenza K, Lazzaro JT, Maklad N, McCarthy SA, Qian W, Rogers BN, Rottas MD, Schmidt CJ, Siuciak JA, Tingley FD 3rd, Zhang AQ. Zhang L, et al. Among authors: zhang aq. J Med Chem. 2011 Mar 24;54(6):1724-39. doi: 10.1021/jm101414h. Epub 2011 Mar 2. J Med Chem. 2011. PMID: 21366332
Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.
O'Donnell CJ, Rogers BN, Bronk BS, Bryce DK, Coe JW, Cook KK, Duplantier AJ, Evrard E, Hajós M, Hoffmann WE, Hurst RS, Maklad N, Mather RJ, McLean S, Nedza FM, O'Neill BT, Peng L, Qian W, Rottas MM, Sands SB, Schmidt AW, Shrikhande AV, Spracklin DK, Wong DF, Zhang A, Zhang L. O'Donnell CJ, et al. Among authors: zhang l, zhang a. J Med Chem. 2010 Feb 11;53(3):1222-37. doi: 10.1021/jm9015075. J Med Chem. 2010. PMID: 20043678
PET Quantification in Healthy Humans of Cyclooxygenase-2, a Potential Biomarker of Neuroinflammation.
Yan X, Noergaard M, Morse CL, Liow JS, Hong J, Greve D, Telu S, Kim MJ, Montero Santamaria JA, Galassi A, Feng N, Williams Avram SK, Usdin TB, Wu S, Zhang A, Manly LS, Jenkins M, Van Buskirk M, Lee A, Zoghbi SS, Pike VW, Zanotti-Fregonara P, Innis RB. Yan X, et al. Among authors: zhang a. J Nucl Med. 2025 Jan 23:jnumed.124.268525. doi: 10.2967/jnumed.124.268525. Online ahead of print. J Nucl Med. 2025. PMID: 39848764
RELMβ sets the threshold for microbiome-dependent oral tolerance.
Stephen-Victor E, Kuziel GA, Martinez-Blanco M, Jugder BE, Benamar M, Wang Z, Chen Q, Lozano GL, Abdel-Gadir A, Cui Y, Fong J, Saint-Denis E, Chang I, Nadeau KC, Phipatanakul W, Zhang A, Farraj FA, Holder-Niles F, Zeve D, Breault DT, Schmitz-Abe K, Rachid R, Crestani E, Rakoff-Nahoum S, Chatila TA. Stephen-Victor E, et al. Among authors: zhang a. Nature. 2025 Jan 22. doi: 10.1038/s41586-024-08440-7. Online ahead of print. Nature. 2025. PMID: 39843735
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