Brocklehurst KJ - Search Results

1

Discovery, optimisation and in vivo evaluation of novel GPR119 agonists.

Brocklehurst KJ, Broo A, Butlin RJ, Brown HS, Clarke DS, Davidsson Ö, Goldberg K, Groombridge SD, Kelly EE, Leach A, McKerrecher D, O'Donnell C, Poucher S, Schofield P, Scott JS, Teague J, Westgate L, Wood MJ. Brocklehurst KJ, et al. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7310-6. doi: 10.1016/j.bmcl.2011.10.033. Epub 2011 Oct 18. Bioorg Med Chem Lett. 2011. PMID: 22061639

2

Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation.

Scott JS, Birch AM, Brocklehurst KJ, Broo A, Brown HS, Butlin RJ, Clarke DS, Davidsson O, Ertan A, Goldberg K, Groombridge SD, Hudson JA, Laber D, Leach AG, Macfaul PA, McKerrecher D, Pickup A, Schofield P, Svensson PH, Sörme P, Teague J. Scott JS, et al. Among authors: brocklehurst kj. J Med Chem. 2012 Jun 14;55(11):5361-79. doi: 10.1021/jm300310c. Epub 2012 May 17. J Med Chem. 2012. PMID: 22545772

3

Conformational restriction in a series of GPR119 agonists: differences in pharmacology between mouse and human.

Scott JS, Brocklehurst KJ, Brown HS, Clarke DS, Coe H, Groombridge SD, Laber D, MacFaul PA, McKerrecher D, Schofield P. Scott JS, et al. Among authors: brocklehurst kj. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3175-9. doi: 10.1016/j.bmcl.2013.04.006. Epub 2013 Apr 10. Bioorg Med Chem Lett. 2013. PMID: 23628336

4

Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists.

Scott JS, Bowker SS, Brocklehurst KJ, Brown HS, Clarke DS, Easter A, Ertan A, Goldberg K, Hudson JA, Kavanagh S, Laber D, Leach AG, MacFaul PA, Martin EA, McKerrecher D, Schofield P, Svensson PH, Teague J. Scott JS, et al. Among authors: brocklehurst kj. J Med Chem. 2014 Nov 13;57(21):8984-98. doi: 10.1021/jm5011012. Epub 2014 Nov 3. J Med Chem. 2014. PMID: 25286150

5

Upregulation of β-cell genes and improved function in rodent islets following chronic glucokinase activation.

Gill D, Brocklehurst KJ, Brown HW, Smith DM. Gill D, et al. Among authors: brocklehurst kj. J Mol Endocrinol. 2011 Jul 18;47(1):59-67. doi: 10.1530/JME-10-0157. Print 2011 Aug. J Mol Endocrinol. 2011. PMID: 21571864

6

The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119.

Stone VM, Dhayal S, Smith DM, Lenaghan C, Brocklehurst KJ, Morgan NG. Stone VM, et al. Among authors: brocklehurst kj. Br J Pharmacol. 2012 Apr;165(8):2758-70. doi: 10.1111/j.1476-5381.2011.01755.x. Br J Pharmacol. 2012. PMID: 22029844 Free PMC article.

7

Increased expression of several components of the ATP dependant proteosome pathway in denervated rat muscle is reversed by beta 2-adrenergic agonists.

Waddell ID, Ruddock P, Brocklehurst KJ, Wilbraham JM, Worral V, Holloway BR. Waddell ID, et al. Among authors: brocklehurst kj. Biochem Soc Trans. 1998 Nov;26(4):S311. doi: 10.1042/bst026s311. Biochem Soc Trans. 1998. PMID: 10047825 No abstract available.

8

Anabolic effects of a range of beta 2-adrenoceptor agonists in a clonal G8.P8 cell line.

Blackburn SJ, Brocklehurst KJ, Thorpe KA, Holloway BR, Waddell ID. Blackburn SJ, et al. Among authors: brocklehurst kj. Biochem Soc Trans. 1996 May;24(2):214S. doi: 10.1042/bst024214s. Biochem Soc Trans. 1996. PMID: 8736872 No abstract available.

9

Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators.

Brocklehurst KJ, Payne VA, Davies RA, Carroll D, Vertigan HL, Wightman HJ, Aiston S, Waddell ID, Leighton B, Coghlan MP, Agius L. Brocklehurst KJ, et al. Diabetes. 2004 Mar;53(3):535-41. doi: 10.2337/diabetes.53.3.535. Diabetes. 2004. PMID: 14988235

10

Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase.

Sullivan JE, Brocklehurst KJ, Marley AE, Carey F, Carling D, Beri RK. Sullivan JE, et al. Among authors: brocklehurst kj. FEBS Lett. 1994 Oct 10;353(1):33-6. doi: 10.1016/0014-5793(94)01006-4. FEBS Lett. 1994. PMID: 7926017 Free article.

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