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Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons.
Pedarzani P, McCutcheon JE, Rogge G, Jensen BS, Christophersen P, Hougaard C, Strøbaek D, Stocker M. Pedarzani P, et al. Among authors: hougaard c. J Biol Chem. 2005 Dec 16;280(50):41404-11. doi: 10.1074/jbc.M509610200. Epub 2005 Oct 20. J Biol Chem. 2005. PMID: 16239218 Free article.
Subtype-specific, bi-component inhibition of SK channels by low internal pH.
Peitersen T, Hougaard C, Jespersen T, Jorgensen NK, Olesen SP, Grunnet M. Peitersen T, et al. Among authors: hougaard c. Biochem Biophys Res Commun. 2006 May 12;343(3):943-9. doi: 10.1016/j.bbrc.2006.03.026. Epub 2006 Mar 20. Biochem Biophys Res Commun. 2006. PMID: 16566895
Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons.
Strøbaek D, Hougaard C, Johansen TH, Sørensen US, Nielsen EØ, Nielsen KS, Taylor RD, Pedarzani P, Christophersen P. Strøbaek D, et al. Among authors: hougaard c. Mol Pharmacol. 2006 Nov;70(5):1771-82. doi: 10.1124/mol.106.027110. Epub 2006 Aug 22. Mol Pharmacol. 2006. PMID: 16926279
A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo.
Hougaard C, Fraser MO, Chien C, Bookout A, Katofiasc M, Jensen BS, Rode F, Bitsch-Nørhave J, Teuber L, Thor KB, Strøbaek D, Burgard EC, Rønn LC. Hougaard C, et al. J Pharmacol Exp Ther. 2009 Jan;328(1):28-39. doi: 10.1124/jpet.108.143123. Epub 2008 Sep 26. J Pharmacol Exp Ther. 2009. PMID: 18820135
Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment.
Hougaard C, Jensen ML, Dale TJ, Miller DD, Davies DJ, Eriksen BL, Strøbaek D, Trezise DJ, Christophersen P. Hougaard C, et al. Mol Pharmacol. 2009 Sep;76(3):569-78. doi: 10.1124/mol.109.056663. Epub 2009 Jun 10. Mol Pharmacol. 2009. PMID: 19515965
65 results