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Page 1
Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents.
McGuigan C, Madela K, Aljarah M, Bourdin C, Arrica M, Barrett E, Jones S, Kolykhalov A, Bleiman B, Bryant KD, Ganguly B, Gorovits E, Henson G, Hunley D, Hutchins J, Muhammad J, Obikhod A, Patti J, Walters CR, Wang J, Vernachio J, Ramamurty CV, Battina SK, Chamberlain S. McGuigan C, et al. Among authors: obikhod a. J Med Chem. 2011 Dec 22;54(24):8632-45. doi: 10.1021/jm2011673. Epub 2011 Nov 16. J Med Chem. 2011. PMID: 22039920
Synthesis and evaluation against hepatitis C virus of 7-deaza analogues of 2'-C-methyl-6-O-methyl guanosine nucleoside and L-Alanine ester phosphoramidates.
Bourdin C, McGuigan C, Brancale A, Chamberlain S, Vernachio J, Hutchins J, Gorovits E, Kolykhalov A, Muhammad J, Patti J, Henson G, Bleiman B, Bryant KD, Ganguly B, Hunley D, Obikhod A, Walters CR, Wang J, Ramamurty CV, Battina SK, Srivinas Rao C. Bourdin C, et al. Among authors: obikhod a. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2260-4. doi: 10.1016/j.bmcl.2012.12.004. Epub 2012 Dec 20. Bioorg Med Chem Lett. 2013. PMID: 23453067
Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus.
Zhang HW, Coats SJ, Bondada L, Amblard F, Detorio M, Asif G, Fromentin E, Solomon S, Obikhod A, Whitaker T, Sluis-Cremer N, Mellors JW, Schinazi RF. Zhang HW, et al. Among authors: obikhod a. Bioorg Med Chem Lett. 2010 Jan 1;20(1):60-4. doi: 10.1016/j.bmcl.2009.11.031. Epub 2009 Nov 13. Bioorg Med Chem Lett. 2010. PMID: 19948402 Free PMC article.
Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans.
van Maarseveen NM, Wensing AM, de Jong D, Beilhartz GL, Obikhod A, Tao S, Pingen M, Arends JE, Hoepelman AI, Schinazi RF, Götte M, Nijhuis M. van Maarseveen NM, et al. Among authors: obikhod a. Antivir Ther. 2011;16(7):1123-30. doi: 10.3851/IMP1912. Antivir Ther. 2011. PMID: 22024528 Free PMC article.
18 results