Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

11 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Publication Date timeline is not available.
Page 1
Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents.
McGuigan C, Madela K, Aljarah M, Bourdin C, Arrica M, Barrett E, Jones S, Kolykhalov A, Bleiman B, Bryant KD, Ganguly B, Gorovits E, Henson G, Hunley D, Hutchins J, Muhammad J, Obikhod A, Patti J, Walters CR, Wang J, Vernachio J, Ramamurty CV, Battina SK, Chamberlain S. McGuigan C, et al. Among authors: aljarah m. J Med Chem. 2011 Dec 22;54(24):8632-45. doi: 10.1021/jm2011673. Epub 2011 Nov 16. J Med Chem. 2011. PMID: 22039920
Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.
McGuigan C, Gilles A, Madela K, Aljarah M, Holl S, Jones S, Vernachio J, Hutchins J, Ames B, Bryant KD, Gorovits E, Ganguly B, Hunley D, Hall A, Kolykhalov A, Liu Y, Muhammad J, Raja N, Walters R, Wang J, Chamberlain S, Henson G. McGuigan C, et al. Among authors: aljarah m. J Med Chem. 2010 Jul 8;53(13):4949-57. doi: 10.1021/jm1003792. J Med Chem. 2010. PMID: 20527890
Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus.
McGuigan C, Madela K, Aljarah M, Gilles A, Brancale A, Zonta N, Chamberlain S, Vernachio J, Hutchins J, Hall A, Ames B, Gorovits E, Ganguly B, Kolykhalov A, Wang J, Muhammad J, Patti JM, Henson G. McGuigan C, et al. Among authors: aljarah m. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4850-4. doi: 10.1016/j.bmcl.2010.06.094. Epub 2010 Jun 20. Bioorg Med Chem Lett. 2010. PMID: 20637609
INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties.
Vernachio JH, Bleiman B, Bryant KD, Chamberlain S, Hunley D, Hutchins J, Ames B, Gorovits E, Ganguly B, Hall A, Kolykhalov A, Liu Y, Muhammad J, Raja N, Walters CR, Wang J, Williams K, Patti JM, Henson G, Madela K, Aljarah M, Gilles A, McGuigan C. Vernachio JH, et al. Among authors: aljarah m. Antimicrob Agents Chemother. 2011 May;55(5):1843-51. doi: 10.1128/AAC.01335-10. Epub 2011 Feb 28. Antimicrob Agents Chemother. 2011. PMID: 21357300 Free PMC article.
Synthesis of 3'-deoxy-3'-C-methyl nucleoside derivatives.
Aljarah M, Couturier S, Mathé C, Périgaud C. Aljarah M, et al. Bioorg Med Chem. 2008 Aug 1;16(15):7436-42. doi: 10.1016/j.bmc.2008.06.011. Epub 2008 Jun 13. Bioorg Med Chem. 2008. PMID: 18579389
Revisited 3'-deoxy-3'-C-methyl-beta-D-ribonucleoside series.
Aljarah M, Couturier S, Gosselin G, Mathé C, Périgaud C. Aljarah M, et al. Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):1125-8. doi: 10.1080/15257770701521730. Nucleosides Nucleotides Nucleic Acids. 2007. PMID: 18058550
Toward the Scale-Up of a Bicyclic Homopiperazine via Schmidt Rearrangement and Photochemical Oxaziridine Rearrangement in Continuous-Flow.
Brown M, Aljarah M, Asiki H, Leung LMH, Smithen DA, Miller N, Nemeth G, Davies L, Niculescu-Duvaz D, Zambon A, Springer C. Brown M, et al. Among authors: aljarah m. Org Process Res Dev. 2021 Jan 15;25(1):148-156. doi: 10.1021/acs.oprd.0c00361. Epub 2020 Oct 15. Org Process Res Dev. 2021. PMID: 33679122 Free PMC article.
2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth.
Smithen DA, Leung LMH, Challinor M, Lawrence R, Tang H, Niculescu-Duvaz D, Pearce SP, Mcleary R, Lopes F, Aljarah M, Brown M, Johnson L, Thomson G, Marais R, Springer C. Smithen DA, et al. Among authors: aljarah m. J Med Chem. 2020 Mar 12;63(5):2308-2324. doi: 10.1021/acs.jmedchem.9b01112. Epub 2019 Sep 4. J Med Chem. 2020. PMID: 31430136 Free PMC article.
11 results