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Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells.
Eskew JD, Sadikot T, Morales P, Duren A, Dunwiddie I, Swink M, Zhang X, Hembruff S, Donnelly A, Rajewski RA, Blagg BS, Manjarrez JR, Matts RL, Holzbeierlein JM, Vielhauer GA. Eskew JD, et al. Among authors: matts rl. BMC Cancer. 2011 Oct 31;11:468. doi: 10.1186/1471-2407-11-468. BMC Cancer. 2011. PMID: 22039910 Free PMC article.
KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells.
Shelton SN, Shawgo ME, Matthews SB, Lu Y, Donnelly AC, Szabla K, Tanol M, Vielhauer GA, Rajewski RA, Matts RL, Blagg BS, Robertson JD. Shelton SN, et al. Among authors: matts rl. Mol Pharmacol. 2009 Dec;76(6):1314-22. doi: 10.1124/mol.109.058545. Epub 2009 Sep 9. Mol Pharmacol. 2009. PMID: 19741006 Free PMC article.
A systematic protocol for the characterization of Hsp90 modulators.
Matts RL, Brandt GE, Lu Y, Dixit A, Mollapour M, Wang S, Donnelly AC, Neckers L, Verkhivker G, Blagg BS. Matts RL, et al. Bioorg Med Chem. 2011 Jan 1;19(1):684-92. doi: 10.1016/j.bmc.2010.10.029. Epub 2010 Oct 19. Bioorg Med Chem. 2011. PMID: 21129982 Free PMC article.
Identification and initial SAR of silybin: an Hsp90 inhibitor.
Zhao H, Brandt GE, Galam L, Matts RL, Blagg BS. Zhao H, et al. Among authors: matts rl. Bioorg Med Chem Lett. 2011 May 1;21(9):2659-64. doi: 10.1016/j.bmcl.2010.12.088. Epub 2010 Dec 28. Bioorg Med Chem Lett. 2011. PMID: 21273068
Gambogic acid, a natural product inhibitor of Hsp90.
Davenport J, Manjarrez JR, Peterson L, Krumm B, Blagg BS, Matts RL. Davenport J, et al. Among authors: matts rl. J Nat Prod. 2011 May 27;74(5):1085-92. doi: 10.1021/np200029q. Epub 2011 Apr 12. J Nat Prod. 2011. PMID: 21486005 Free PMC article.
89 results