Jackson J - Search Results

1

Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-β (TGF-β).

Lin S, Yu L, Yang J, Liu Z, Karia B, Bishop AJR, Jackson J, Lozano G, Copland JA, Mu X, Sun B, Sun LZ. Lin S, et al. Among authors: jackson j. J Biol Chem. 2011 Dec 23;286(51):44023-44034. doi: 10.1074/jbc.M111.265397. Epub 2011 Oct 28. J Biol Chem. 2011. PMID: 22039050 Free PMC article.

2

A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.

Post SM, Quintás-Cardama A, Pant V, Iwakuma T, Hamir A, Jackson JG, Maccio DR, Bond GL, Johnson DG, Levine AJ, Lozano G. Post SM, et al. Among authors: jackson jg. Cancer Cell. 2010 Sep 14;18(3):220-30. doi: 10.1016/j.ccr.2010.07.010. Cancer Cell. 2010. PMID: 20832750 Free PMC article.

3

Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.

Jackson JG, Post SM, Lozano G. Jackson JG, et al. J Pathol. 2011 Jan;223(2):127-36. doi: 10.1002/path.2783. Epub 2010 Oct 18. J Pathol. 2011. PMID: 20957626 Review.

4

Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity.

Abbas HA, Maccio DR, Coskun S, Jackson JG, Hazen AL, Sills TM, You MJ, Hirschi KK, Lozano G. Abbas HA, et al. Cell Stem Cell. 2010 Nov 5;7(5):606-17. doi: 10.1016/j.stem.2010.09.013. Cell Stem Cell. 2010. PMID: 21040902 Free PMC article.

5

Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation.

Wang Y, Suh YA, Fuller MY, Jackson JG, Xiong S, Terzian T, Quintás-Cardama A, Bankson JA, El-Naggar AK, Lozano G. Wang Y, et al. J Clin Invest. 2011 Mar;121(3):893-904. doi: 10.1172/JCI44504. J Clin Invest. 2011. PMID: 21285512 Free PMC article.

6

Multiple stress signals activate mutant p53 in vivo.

Suh YA, Post SM, Elizondo-Fraire AC, Maccio DR, Jackson JG, El-Naggar AK, Van Pelt C, Terzian T, Lozano G. Suh YA, et al. Cancer Res. 2011 Dec 1;71(23):7168-75. doi: 10.1158/0008-5472.CAN-11-0459. Epub 2011 Oct 7. Cancer Res. 2011. PMID: 21983037 Free PMC article.

7

p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.

Jackson JG, Pant V, Li Q, Chang LL, Quintás-Cardama A, Garza D, Tavana O, Yang P, Manshouri T, Li Y, El-Naggar AK, Lozano G. Jackson JG, et al. Cancer Cell. 2012 Jun 12;21(6):793-806. doi: 10.1016/j.ccr.2012.04.027. Cancer Cell. 2012. PMID: 22698404 Free PMC article.

8

Che-ating death: CHE1/AATF protects from p53-mediated apoptosis.

Jackson JG, Lozano G. Jackson JG, et al. EMBO J. 2012 Oct 17;31(20):3951-3. doi: 10.1038/emboj.2012.258. Epub 2012 Sep 7. EMBO J. 2012. PMID: 22960635 Free PMC article.

9

The mutant p53 mouse as a pre-clinical model.

Jackson JG, Lozano G. Jackson JG, et al. Oncogene. 2013 Sep 12;32(37):4325-30. doi: 10.1038/onc.2012.610. Epub 2013 Jan 14. Oncogene. 2013. PMID: 23318424 Review.

10

The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity.

Pant V, Xiong S, Jackson JG, Post SM, Abbas HA, Quintás-Cardama A, Hamir AN, Lozano G. Pant V, et al. Genes Dev. 2013 Sep 1;27(17):1857-67. doi: 10.1101/gad.227249.113. Epub 2013 Aug 23. Genes Dev. 2013. PMID: 23973961 Free PMC article.

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