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MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212.
La Rosa V, Poce G, Canseco JO, Buroni S, Pasca MR, Biava M, Raju RM, Porretta GC, Alfonso S, Battilocchio C, Javid B, Sorrentino F, Ioerger TR, Sacchettini JC, Manetti F, Botta M, De Logu A, Rubin EJ, De Rossi E. La Rosa V, et al. Among authors: porretta gc. Antimicrob Agents Chemother. 2012 Jan;56(1):324-31. doi: 10.1128/AAC.05270-11. Epub 2011 Oct 24. Antimicrob Agents Chemother. 2012. PMID: 22024828 Free PMC article.
Antimycobacterial compounds. New pyrrole derivatives of BM212.
Biava M, Porretta GC, Deidda D, Pompei R, Tafi A, Manetti F. Biava M, et al. Among authors: porretta gc. Bioorg Med Chem. 2004 Mar 15;12(6):1453-8. doi: 10.1016/j.bmc.2003.12.037. Bioorg Med Chem. 2004. PMID: 15018918
Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection.
Poce G, Bates RH, Alfonso S, Cocozza M, Porretta GC, Ballell L, Rullas J, Ortega F, De Logu A, Agus E, La Rosa V, Pasca MR, De Rossi E, Wae B, Franzblau SG, Manetti F, Botta M, Biava M. Poce G, et al. Among authors: porretta gc. PLoS One. 2013;8(2):e56980. doi: 10.1371/journal.pone.0056980. Epub 2013 Feb 21. PLoS One. 2013. PMID: 23437287 Free PMC article.
59 results