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Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output.
Baghdasaryan A, Claudel T, Gumhold J, Silbert D, Adorini L, Roda A, Vecchiotti S, Gonzalez FJ, Schoonjans K, Strazzabosco M, Fickert P, Trauner M. Baghdasaryan A, et al. Among authors: silbert d. Hepatology. 2011 Oct;54(4):1303-12. doi: 10.1002/hep.24537. Hepatology. 2011. PMID: 22006858 Free PMC article.
Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-/- mice.
Halilbasic E, Fiorotto R, Fickert P, Marschall HU, Moustafa T, Spirli C, Fuchsbichler A, Gumhold J, Silbert D, Zatloukal K, Langner C, Maitra U, Denk H, Hofmann AF, Strazzabosco M, Trauner M. Halilbasic E, et al. Among authors: silbert d. Hepatology. 2009 Jun;49(6):1972-81. doi: 10.1002/hep.22891. Hepatology. 2009. PMID: 19475687 Free PMC article.
Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury.
Moustafa T, Fickert P, Magnes C, Guelly C, Thueringer A, Frank S, Kratky D, Sattler W, Reicher H, Sinner F, Gumhold J, Silbert D, Fauler G, Höfler G, Lass A, Zechner R, Trauner M. Moustafa T, et al. Among authors: silbert d. Gastroenterology. 2012 Jan;142(1):140-151.e12. doi: 10.1053/j.gastro.2011.09.051. Epub 2011 Oct 14. Gastroenterology. 2012. PMID: 22001865
Bile acids trigger cholemic nephropathy in common bile-duct-ligated mice.
Fickert P, Krones E, Pollheimer MJ, Thueringer A, Moustafa T, Silbert D, Halilbasic E, Yang M, Jaeschke H, Stokman G, Wells RG, Eller K, Rosenkranz AR, Eggertsen G, Wagner CA, Langner C, Denk H, Trauner M. Fickert P, et al. Among authors: silbert d. Hepatology. 2013 Dec;58(6):2056-69. doi: 10.1002/hep.26599. Epub 2013 Oct 15. Hepatology. 2013. PMID: 23813550
196 results